L-Phenylalanine, 4-fluoro-3-nitro-N-(trifluoroacetyl)-

Base Information

Chemical Name:L-Phenylalanine, 4-fluoro-3-nitro-N-(trifluoroacetyl)-
CAS No.:188624-28-4
Molecular Formula:C₁₁H₈F₄N₂O₅
Molecular Weight:324.189
Hs Code.:

Synonyms:

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Chemical Property of L-Phenylalanine, 4-fluoro-3-nitro-N-(trifluoroacetyl)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of L-Phenylalanine, 4-fluoro-3-nitro-N-(trifluoroacetyl)-

There total 5 articles about L-Phenylalanine, 4-fluoro-3-nitro-N-(trifluoroacetyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 188624-24-0
(RS)-N-trifluoroacetyl-4-fluoro-3-nitrophenylalanine methyl ester

: 188624-28-4
(S)-N-trifluoroacetyl-4-fluoro-3-nitrophenylalanine

Guidance literature:: With phosphate buffer; subtilisin carlsberg (Bacillus subtilis); In dichloromethane; at 37 ℃; for 6h;
DOI:10.1016/S0957-4166(96)00524-1

Reference yield:

: 20367-99-1
ethyl 2-(acetylamino)-2-(ethoxycarbonyl)-3-(4'-fluoro-3'-nitrophenyl)propanoate

: 188624-28-4
(S)-N-trifluoroacetyl-4-fluoro-3-nitrophenylalanine

Guidance literature:: Multi-step reaction with 4 steps

1: conc. aq. HCl / 20 h / Heating

2: SOCl₂ / 5 h / 40 °C

3: Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

4: phosphate buffer, subtilisin carlsberg (Bacillus subtilis) / CH₂Cl₂ / 6 h / 37 °C

With hydrogenchloride; thionyl chloride; phosphate buffer; subtilisin carlsberg (Bacillus subtilis); triethylamine; In dichloromethane;
DOI:10.1016/S0957-4166(96)00524-1

Reference yield:

: 15017-52-4
4-(bromomethyl)-1-fluoro-2-nitrobenzene

: 188624-28-4
(S)-N-trifluoroacetyl-4-fluoro-3-nitrophenylalanine

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / NaH / dimethylformamide / 4 h / Ambient temperature

2: conc. aq. HCl / 20 h / Heating

3: SOCl₂ / 5 h / 40 °C

4: Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

5: phosphate buffer, subtilisin carlsberg (Bacillus subtilis) / CH₂Cl₂ / 6 h / 37 °C

With hydrogenchloride; thionyl chloride; phosphate buffer; subtilisin carlsberg (Bacillus subtilis); sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0957-4166(96)00524-1