N-Butyl-3-hydroxypyridine-2-carboxamide

Base Information

Chemical Name:N-Butyl-3-hydroxypyridine-2-carboxamide
CAS No.:1079-41-0
Molecular Formula:C10H14 N2 O2
Molecular Weight:194.233
Hs Code.:2933399090
European Community (EC) Number:214-092-7
DSSTox Substance ID:DTXSID50148320
Nikkaji Number:J217.203H
Wikidata:Q83013835
ChEMBL ID:CHEMBL3924022
Mol file:1079-41-0.mol

Synonyms:N-Butyl-3-hydroxypyridine-2-carboxamide;1079-41-0;EINECS 214-092-7;SCHEMBL8358319;CHEMBL3924022;DTXSID50148320;N-Butyl-3-hydroxy-2-pyridinecarboxamide

Suppliers and Price of N-Butyl-3-hydroxypyridine-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of N-Butyl-3-hydroxypyridine-2-carboxamide

Chemical Property:

Vapor Pressure:3.85E-09mmHg at 25°C
Boiling Point:461.6°Cat760mmHg
Flash Point:233°C
PSA：65.71000
Density:1.136g/cm³
LogP:1.89190
XLogP3:2.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:194.105527694
Heavy Atom Count:14
Complexity:185

Purity/Quality:: 98%,99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCNC(=O)C1=C(C=CC=N1)O

Technology Process of N-Butyl-3-hydroxypyridine-2-carboxamide

There total 2 articles about N-Butyl-3-hydroxypyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 874-24-8
3-hydroxypyridine-2-carboxylic acid

: 109-73-9,85404-21-3
N-butylamine

: 1079-41-0
N-n-butyl-3-hydroxy-2-pyridinecarboxamide

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 50 ℃; for 2h; Microwave irradiation;
DOI:10.1016/j.ejmech.2016.10.045

Reference yield: 88.0%

: 1079-41-0
N-n-butyl-3-hydroxy-2-pyridinecarboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

In N,N-dimethyl-formamide; at 50 ℃; for 2h; Microwave irradiation;

Reference yield:

: 1079-41-0
N-n-butyl-3-hydroxy-2-pyridinecarboxamide

: N-butyl-N-(4-fluorobenzyl)-3-(methoxymethoxy)picolinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

1.2: 36.17 h / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 8 h / 0 - 20 °C / Inert atmosphere

With sodium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2016.10.045