Ethambutol dihydrochloride

Base Information

• Chemical Name: Ethambutol dihydrochloride
• CAS No.: 1070-11-7
• Molecular Formula: C₁₀H₂₄N₂O₂*2ClH
• Molecular Weight: 277.235
• Hs Code.: 29419000
• European Community (EC) Number: 213-970-7
• UNII: JNG307DJ5X,QE4VW5FO07
• DSSTox Substance ID: DTXSID4045345
• Wikidata: Q27106530
• NCI Thesaurus Code: C29033
• RXCUI: 142435
• ChEMBL ID: CHEMBL3140361
• Mol file: 1070-11-7.mol

Synonyms:(+)-2,2-(Ethylenediimino)-di-1-butanol dihydrochloride;Prestwick_208;(2S)-2-[2-[[(2S)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol dihydrochloride;1-Butanol, 2,2-(1,2-ethanediyldiimino)bis-, dihydrochloride, (R-(R*,R*))- (9CI);Ethambutol hydrochloride;CL 40881;(S-(R*,R*))-2,2-(Ethylenediimino)dibutan-1-ol dihydrochloride;1-Butanol,2,2'-(1,2-ethanediyldiimino)bis-,dihydrochloride,(2S,2'S)-;Ethambutol hydrochloride (JP14/USP);Myambutol;1-Butanol, 2,2-(1,2-ethanediyldiimino)bis-, dihydrochloride, (S-(R*,R*))-;Ethambutol hydrochloride [USAN:JAN];(2R)-2-[2-[[(2R)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol dihydrochloride;Myambutol (TN);Ethambutol HCl;

Chemical Property of Ethambutol dihydrochloride

Chemical Property:

• Appearance/Colour: white powder
• Vapor Pressure: 3.35E-07mmHg at 25°C
• Melting Point: 198-200 °C
• Boiling Point: 345.3 °C at 760 mmHg
• Flash Point: 113.7 °C
• PSA: 64.52000
• LogP: 2.09320
• Storage Temp.: Refrigerator
• Solubility.: H2O: soluble50mg/mL
• Water Solubility.: Slightly soluble in water
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 9
• Exact Mass: 276.1371335
• Heavy Atom Count: 16
• Complexity: 109

Purity/Quality:

99% ^*data from raw suppliers

Ethambutol dihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T,Xi
• Hazard Codes: T,Xi
• Statements: 61-36/37/38
• Safety Statements: 53-22-36/37/39-45-36/37-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCC(CO)NCCNC(CC)CO.Cl.Cl
• Isomeric SMILES: CC[C@@H](CO)NCCN[C@@H](CC)CO.Cl.Cl
• Recent ClinicalTrials: The Treatment of Tuberculosis in HIV-Infected Patients
• Recent EU Clinical Trials: Rifapentine-containing treatment shortening regimens for pulmonary tuberculosis:
• Uses: Antibacterial (tuberculostatic) Antituberculous Ethambutol dihydrochloride it acts as a tuberculostatic antibacterial agent. It is used to treat tuberculosis in combination with other antibiotics to reduce the development of drug resistance. It has been used to study multidrug-resistant tuberculosis (MDR-TB) in highest-incidence-rate.
• Therapeutic Function: Antitubercular
• Clinical Use: Antibacterial agent:Tuberculosis
• Drug interactions: Potentially hazardous interactions with other drugs None known