6-CHLORO-1-(4-CHLOROPHENYL)-1-OXOHEXANE

Base Information

• Chemical Name: 6-CHLORO-1-(4-CHLOROPHENYL)-1-OXOHEXANE
• CAS No.: 188851-40-3
• Molecular Formula: C₁₂H₁₄Cl₂O
• Molecular Weight: 245.149
• Hs Code.: 2914700090
• Mol file: 188851-40-3.mol

Synonyms:1-Hexanone,6-chloro-1-(4-chlorophenyl);6-CHLORO-1-(4-CHLOROPHENYL)-1-OXOHEXANE;

Chemical Property of 6-CHLORO-1-(4-CHLOROPHENYL)-1-OXOHEXANE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 363.284oC at 760 mmHg
• Flash Point: 153.536oC
• PSA: 17.07000
• Density: 1.166g/cm3
• LogP: 4.32190

Purity/Quality:

99.90% ^*data from raw suppliers

6-chloro-1-(4-chlorophenyl)-1-oxohexane 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-CHLORO-1-(4-CHLOROPHENYL)-1-OXOHEXANE

There total 2 articles about 6-CHLORO-1-(4-CHLOROPHENYL)-1-OXOHEXANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-(4-chlorophenyl)cyclohexan-1-ol (17380-83-5) → 6-chloro-1-(4-chlorophenyl)hexan-1-one (188851-40-3)

Guidance literature:

With 1,10-Phenanthroline; tert-butylhypochlorite; silver trifluoromethanesulfonate; In acetonitrile; at 20 ℃; for 48h; regioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.5b03649

Reference yield: 78.0%

1-Chloro-4-iodobenzene (637-87-6) + 6-chlorohexanoyl chloride (19347-73-0) → 6-chloro-1-(4-chlorophenyl)hexan-1-one (188851-40-3)

Guidance literature:

With manganese(II) iodide; n-butyllithium; In diethyl ether;

DOI:10.1016/S0040-4039(97)00248-7

upstream raw materials:

1-Chloro-4-iodobenzene

6-chlorohexanoyl chloride

1-(4-chlorophenyl)cyclohexan-1-ol

Refernces

• 1、 Klement, Ingo,Stadtmueller, Heinz,Knochel, Paul,Cahiez, Gerard. "Preparation and reactivity of functionalized aryl and alkenylmanganese halides". . p. 1927 - 1930. Retrieved 2007/10/03.