1-phenyl-2,3,4,9-tetrahydro-1H-beta-carboline hydrochloride

Base Information

• Chemical Name: 1-phenyl-2,3,4,9-tetrahydro-1H-beta-carboline hydrochloride
• CAS No.: 3574-01-4
• Molecular Formula: C17H17ClN2
• Molecular Weight: 284.788
• Hs Code.: 2933990090
• Mol file: 3574-01-4.mol

Synonyms:9H-Pyrido(3,4-b)indole,1,2,3,4-tetrahydro-1-phenyl-,hydrochloride;1-phenyl-2,3,4,9-tetrahydro-1H-pyrido<3,4-b>indole hydrochloride;9H-Pyrido(3,4-b)indole,1,2,3,4-tetrahydro-1-phenyl-,monohydrochloride;1-Phenyltetrahydronorharman hydrochloride;

Chemical Property of 1-phenyl-2,3,4,9-tetrahydro-1H-beta-carboline hydrochloride

Chemical Property:

• Vapor Pressure: 4.19E-08mmHg at 25°C
• Melting Point: 254-258 °C(Solv: ethanol (64-17-5))
• Boiling Point: 444.7°Cat760mmHg
• Flash Point: 222.7°C
• PSA: 27.82000
• Density: g/cm³
• LogP: 4.53380

Purity/Quality:

95% ^*data from raw suppliers

1-Phenyl-2,3,4,9-tetrahydro-1H-beta-carbolinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-phenyl-2,3,4,9-tetrahydro-1H-beta-carboline hydrochloride

There total 7 articles about 1-phenyl-2,3,4,9-tetrahydro-1H-beta-carboline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tryptamine (61-54-1) + benzaldehyde (100-52-7) → 1-phenyl-2,3,4,9-tetrahydro-1H-pyrido<3,4-b>indole hydrochloride (3574-01-4)

Guidance literature:

tryptamine; benzaldehyde; With trifluoroacetic acid; In 1,2-dichloro-ethane; at 110 ℃; for 0.0666667h; Sealed tube; Microwave irradiation;

With hydrogenchloride; In ethyl acetate; at 20 ℃;

DOI:10.1002/ejoc.201301580

Reference yield: 94.0%

tryptamine hydochloride (343-94-2) + benzaldehyde (100-52-7) → 1-phenyl-2,3,4,9-tetrahydro-1H-pyrido<3,4-b>indole hydrochloride (3574-01-4)

Guidance literature:

for 0.05h; microwave irradiation;

DOI:10.1080/00397910701572555

Reference yield: 75.0%

tryptamine-2-carboxylic acid (5956-86-5) + benzaldehyde (100-52-7) → 1-phenyl-2,3,4,9-tetrahydro-1H-pyrido<3,4-b>indole hydrochloride (3574-01-4)

Guidance literature:

With trifluoroacetic acid; In 1,4-dioxane; benzene; for 24h; Product distribution; Mechanism; Heating; other carbonyl compounds, other tryptamine-2-carboxylic acids;

DOI:10.1021/jo00001a066

upstream raw materials:

tryptamine-2-carboxylic acid

benzaldehyde

Benzoylformic acid

1-phenyl-2,3,4,9-tetrahydro-1H-beta-carboline

Downstream raw materials:

1-phenyl-2,3,4,9-tetrahydro-1H-beta-carboline

1-phenyl-9H-pyrido[3,4-b]indole

2-(2-benzyl-1H-indol-3-yl)ethanamine

(R)-1-phenyl-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole

Refernces

• 1、 Eagon, Scott,Anderson, Marc O.. "Microwave-Assisted Synthesis of Tetrahydro-β-carbolines and β-Carbolines". . p. 1653 - 1665. Retrieved 2015/10/05.
• 2、 Ryabukhin, Sergey V.,Panov, Dmitriy M.,Plaskon, Andrey S.,Tolmachev, Andrey A.,Smaliy, Radomyr V.. "Application of chlorotrimethylsilane in Pictet-Spengler reaction". . p. 1507 - 1517. Retrieved 2013/02/21.