6-BroMo-1,1-diMethyl-4-p-tolyl-1,2-dihydro-naphthalene

Base Information

• Chemical Name: 6-BroMo-1,1-diMethyl-4-p-tolyl-1,2-dihydro-naphthalene
• CAS No.: 188889-06-7
• Molecular Formula: C19H19Br
• Molecular Weight: 327.25800
• Mol file: 188889-06-7.mol

Synonyms:6-BroMo-1,1-diMethyl-4-p-tolyl-1,2-dihydro-naphthalene;7-bromo-3,4-dihydro-4,4-dimethyl-1-(4-methylphenyl)-naphthalene;3,4-dihydro-1-(4-methylphenyl)-4,4-dimethyl-7-bromonaphthalene;

Chemical Property of 6-BroMo-1,1-diMethyl-4-p-tolyl-1,2-dihydro-naphthalene

Chemical Property:

• PSA: 0.00000
• LogP: 5.87050

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BroMo-1,1-diMethyl-4-p-tolyl-1,2-dihydro-naphthalene

There total 6 articles about 6-BroMo-1,1-diMethyl-4-p-tolyl-1,2-dihydro-naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

7-bromo-4,4-dimethyl-1-(p-tolyl)-1,2,3,4-tetrahydronaphthalen-1-ol (188889-04-5) → 6-bromo-1,1-dimethyl-4-(p-tolyl)-1,2-dihydronaphthalene (188889-06-7)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 2h; Heating;

DOI:10.1021/jm9703911

Reference yield:

diethyl ether (60-29-7,927820-24-4) + 7-bromo-4,4-dimethyl-1-(p-tolyl)-1,2,3,4-tetrahydronaphthalen-1-ol (188889-04-5) → 6-bromo-1,1-dimethyl-4-(p-tolyl)-1,2-dihydronaphthalene (188889-06-7)

Guidance literature:

p-toluenesulfonic acid monohydrate; In benzene;

Reference yield:

7-bromo-4,4-dimethyl-3,4-dihydro-2H-naphthalen-1-one (166978-46-7) → 6-bromo-1,1-dimethyl-4-(p-tolyl)-1,2-dihydronaphthalene (188889-06-7)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 0 °C

2: p-TSA / methanol

With toluene-4-sulfonic acid; In tetrahydrofuran; methanol;

DOI:10.1016/S0960-894X(99)00077-3

upstream raw materials:

7-bromo-4,4-dimethyl-1-(p-tolyl)-1,2,3,4-tetrahydronaphthalen-1-ol

para-methylphenylmagnesium bromide

7-bromo-4,4-dimethyl-3,4-dihydro-2H-naphthalen-1-one

diethyl ether

Downstream raw materials:

5,6-dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenecarboxylic acid

5,5-dimethyl-8-p-tolyl-5,6-dihydro-naphthalene-2-carbaldehyde

4-{1-[1-[5,5-Dimethyl-8-(5-methyl-thiophen-2-yl)-5,6-dihydro-naphthalen-2-yl]-meth-(E)-ylidene]-3,3-dimethoxy-propyl}-benzoic acid ethyl ester

4-{1-[1-(5,5-Dimethyl-8-p-tolyl-5,6-dihydro-naphthalen-2-yl)-meth-(E)-ylidene]-3,3-dimethoxy-propyl}-benzoic acid ethyl ester