2-(Benzyloxy)-1-cyclopropylethanol

Base Information

• Chemical Name: 2-(Benzyloxy)-1-cyclopropylethanol
• CAS No.: 188896-08-4
• Molecular Formula: C12H16O2
• Molecular Weight: 192.25400
• Hs Code.: 2909499000
• DSSTox Substance ID: DTXSID30570180
• Nikkaji Number: J815.132F
• Mol file: 188896-08-4.mol

Synonyms:2-(benzyloxy)-1-cyclopropylethanol;188896-08-4;1-cyclopropyl-2-phenylmethoxyethanol;2-(Benzyloxy)-1-cyclopropylethan-1-ol;Cyclopropanemethanol, alpha-[(phenylmethoxy)methyl]-;DTXSID30570180;AKOS013220763;SB85159;AM806652

Chemical Property of 2-(Benzyloxy)-1-cyclopropylethanol

Chemical Property:

• Boiling Point: 310.2±17.0 °C(Predicted)
• PKA: 14.33±0.20(Predicted)
• PSA: 29.46000
• Density: 1.131±0.06 g/cm3(Predicted)
• LogP: 1.97410
• Storage Temp.: 2-8°C
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 192.115029749
• Heavy Atom Count: 14
• Complexity: 160

Purity/Quality:

99% ^*data from raw suppliers

2-(Benzyloxy)-1-cyclopropylethanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC1C(COCC2=CC=CC=C2)O

Technology Process of 2-(Benzyloxy)-1-cyclopropylethanol

There total 4 articles about 2-(Benzyloxy)-1-cyclopropylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

benzyloxyacetoaldehyde (60656-87-3) + cyclopropylmagnesium bromide (23719-80-4) → 2-(benzyloxy)-1-cyclopropyl-1-ethanol (188896-08-4)

Guidance literature:

In diethyl ether; for 2h; Heating;

DOI:10.1135/cccc19942069

Reference yield: 52.0%

cis-2-[(benzyloxy)methyl]-3-vinyloxirane → 1-Benzyloxy-penten-(3)-ol-(2) (14869-02-4) + 2-(benzyloxy)-1-cyclopropyl-1-ethanol (188896-08-4)

Guidance literature:

With Schwartz's reagent; sodium hydrogencarbonate; In dichloromethane; Ambient temperature;

DOI:10.1016/S0040-4039(97)00233-5

Reference yield:

cyclopropyl bromide (4333-56-6,130561-87-4) + benzyloxyacetoaldehyde (60656-87-3) → 2-(benzyloxy)-1-cyclopropyl-1-ethanol (188896-08-4)

Guidance literature:

With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 - 20 ℃;

DOI:10.1016/j.bmcl.2010.11.022

upstream raw materials:

benzyloxyacetoaldehyde

cyclopropylmagnesium bromide

(±)-3-((benzyloxy)methyl)oxirane-2-carbaldehyde

cyclopropyl bromide

Downstream raw materials:

1-cyclopropylethane-1,2-diol

C₁₂H₁₅FO