2-(thien-3-yl)propanenitrile

Base Information

• Chemical Name: 2-(thien-3-yl)propanenitrile
• CAS No.: 188908-91-0
• Molecular Formula: C7H7NS
• Molecular Weight: 137.20200
• Mol file: 188908-91-0.mol

Synonyms:2-(3-thienyl)propanenitrile;2-Thiophen-3-yl-propionitrile;2-(thien-3-yl)propanenitrile;

Chemical Property of 2-(thien-3-yl)propanenitrile

Chemical Property:

• PSA: 52.03000
• LogP: 2.37518

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(thien-3-yl)propanenitrile

There total 4 articles about 2-(thien-3-yl)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

2-cyanomethylthiophene (20893-30-5) + methyl iodide (74-88-4) → 2-(thiophen-3-yl)propanenitrile (188908-91-0)

Guidance literature:

2-cyanomethylthiophene; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ja312141b

Reference yield: 55.0%

3-ethynylthiophene (67237-53-0) + 4-cyanopyridine N-oxide (14906-59-3) → 2-(thiophen-3-yl)propanenitrile (188908-91-0)

Guidance literature:

3-ethynylthiophene; 4-cyanopyridine N-oxide; With potassium fluoride; trifluoroacetic acid; nickel dichloride; zinc; In N,N-dimethyl acetamide; at 30 ℃; for 10h;

With sodium tetrahydroborate; In methanol;

DOI:10.1021/acscatal.9b04586

Reference yield: 55.0%

(thiophen-3-yl)acetonitrile (13781-53-8) + methyl iodide (74-88-4) → 2-(thiophen-3-yl)propanenitrile (188908-91-0)

Guidance literature:

(thiophen-3-yl)acetonitrile; With sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In dimethyl sulfoxide; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1039/c3cc40643a

upstream raw materials:

3-Bromothiophene

2-chlorpropionitrile

(thiophen-3-yl)acetonitrile

methyl iodide

Downstream raw materials:

4-methyl-9a-phenyl-7,8,9,9a-tetrahydrothieno[3,2-g]indolizin-5(4H)-one

Refernces

• 1、 Huang, Huawen,Ji, Xiaochen,Wu, Wanqing,Jiang, Huanfeng. "A cascade approach to fused indolizinones through Lewis acid-copper(i) relay catalysis". supporting information. p. 3351 - 3353. Retrieved 2013/06/04.
• 2、 -. "Quinoline and naphthyridine carboxylic acid antibacterials". . . Retrieved 2008/06/13.