2,6-diethylphenylisonitrile

Base Information

• Chemical Name: 2,6-diethylphenylisonitrile
• CAS No.: 2980-92-9
• Molecular Formula: C11H13 N
• Molecular Weight: 159.231
• Hs Code.: 2926909090
• Mol file: 2980-92-9.mol

Synonyms:Phenylisocyanide, 2,6-diethyl- (7CI,8CI); 2,6-Diethylphenyl isocyanide

Chemical Property of 2,6-diethylphenylisonitrile

Chemical Property:

• PSA: 0.00000
• LogP: 2.59290

Purity/Quality:

99%min ^*data from raw suppliers

1,3-DIETHYL-2-ISOCYANO-BENZENE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-diethylphenylisonitrile

There total 4 articles about 2,6-diethylphenylisonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

N-(2,6-diethylphenyl)formamide (39086-39-0) → 2,6-diethylphenyl isocyanide (2980-92-9)

Guidance literature:

N-(2,6-diethylphenyl)formamide; With diisopropylamine; trichlorophosphate; In dichloromethane; at 0 - 20 ℃; for 3.5h;

With sodium carbonate; In dichloromethane; water;

DOI:10.1002/adsc.202101000

Reference yield:

2,6-diethylaniline (579-66-8) → 2,6-diethylphenyl isocyanide (2980-92-9)

Guidance literature:

With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In dichloromethane; chloroform;

Reference yield:

C11H15Cl2N*ClH → 2,6-diethylphenyl isocyanide (2980-92-9)

Guidance literature:

With triethylamine; In dichloromethane; at -60 - 20 ℃;

DOI:10.1002/adsc.201100183

upstream raw materials:

2,6-dimethylphenyl isonitrile

methyl iodide

2,6-diethylaniline

N-(2,6-diethylphenyl)formamide

Downstream raw materials:

2',6'-Diaethyl-N-thioformylbenzanilid

C₁₄H₂₂NOPS₂

N-Thioformyl-2',6'-diaethylpropionanilid

2',6'-Diaethyl-N-thioformyl-2-chloroacetanilid

Refernces

• 1、 Nanjo, Takeshi,Tsukano, Chihiro,Takemoto, Yoshiji. "Palladium-catalyzed cascade process consisting of isocyanide insertion and benzylic C(sp3)-H activation: Concise synthesis of indole derivatives". . p. 4270 - 4273. Retrieved 2012/10/08.
• 2、 Ito,Kobayashi,Seko,Saegusa. "INDOLE SYNTHESES UTILIZING o-METHYLPHENYL ISOCYANIDES.". . p. 73 - 84. Retrieved 2007/10/02.