Levalbuterol Related Compound B (20 mg) (alpha-[{(1,1-Dimethylethyl)amino}methyl]-4-hydroxy-3-methyl-benzenemethanol)

Base Information

Chemical Name:Levalbuterol Related Compound B (20 mg) (alpha-[{(1,1-Dimethylethyl)amino}methyl]-4-hydroxy-3-methyl-benzenemethanol)
CAS No.:18910-68-4
Molecular Formula:C13H21NO2
Molecular Weight:223.315
Hs Code.:2922504500
Mol file:18910-68-4.mol

Synonyms:Salbutamol sulfate impurity C;UNII-152NRR02YD;

Suppliers and Price of Levalbuterol Related Compound B (20 mg) (alpha-[{(1,1-Dimethylethyl)amino}methyl]-4-hydroxy-3-methyl-benzenemethanol)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-DehydroxySalbutamol
50mg
$ 805.00

Medical Isotopes, Inc.
3-DehydroxySalbutamol
100 mg
$ 2400.00

Activate Scientific
4-(2-(tert-Butylamino)-1-hydroxyethyl)-2-methylphenol 97%
5 g
$ 1317.00

Total 23 raw suppliers

Chemical Property of Levalbuterol Related Compound B (20 mg) (alpha-[{(1,1-Dimethylethyl)amino}methyl]-4-hydroxy-3-methyl-benzenemethanol)

Chemical Property:

Melting Point:160-163°C
Boiling Point:378.4±37.0 °C(Predicted)
PKA:10.37±0.31(Predicted)
PSA：52.49000
Density:1.062±0.06 g/cm3(Predicted)
LogP:2.51300
Storage Temp.:2-8°C(protect from light)
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

3-DehydroxySalbutamol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 3-Dehydroxy Salbutamol is an isoprenaline based selective stimulants of β-adrenergic receptors in bronchial muscles. 3-Dehydroxy Salbutamol (Levalbuterol USP Related Compound B; Salbutamol EP Impurity C) is an isoprenaline based selective stimulants of β-adrenergic receptors in bronchial muscles.

Technology Process of Levalbuterol Related Compound B (20 mg) (alpha-[{(1,1-Dimethylethyl)amino}methyl]-4-hydroxy-3-methyl-benzenemethanol)

There total 10 articles about Levalbuterol Related Compound B (20 mg) (alpha-[{(1,1-Dimethylethyl)amino}methyl]-4-hydroxy-3-methyl-benzenemethanol) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.7%

: 2-(Benzyl-tert-butyl-amino)-1-(4-hydroxy-3-hydroxymethyl-phenyl)-ethanone; hydrochloride

: 18910-68-4
2-(tert-butylamino)-1-(4-hydroxyl-3-methylphenyl)ethanol

Guidance literature:: With palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃; for 8h; Temperature;

Reference yield: 63.7%

: 60853-66-9
2-tert-Butylamino-1-(4-hydroxy-3-methyl-phenyl)-ethanone

: 18910-68-4
2-(tert-butylamino)-1-(4-hydroxyl-3-methylphenyl)ethanol

Guidance literature:: With sodium tetrahydroborate; In methanol; at 20 ℃;

Reference yield:

: 2-(Benzyl-tert-butyl-amino)-1-(4-hydroxy-3-hydroxymethyl-phenyl)-ethanone; hydrochloride

: 18559-94-9,34271-50-6
Salbutamol

: 18910-68-4
2-(tert-butylamino)-1-(4-hydroxyl-3-methylphenyl)ethanol

Guidance literature:: 2-(Benzyl-tert-butyl-amino)-1-(4-hydroxy-3-hydroxymethyl-phenyl)-ethanone; hydrochloride; With 5%-palladium/activated carbon; hydrogen; In methanol; at 20 ℃; for 1h; under 760.051 Torr;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 0.5h; Overall yield = 1.49 g;
DOI:10.1021/acs.oprd.7b00261