L-Histidinamide, N-[6-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxohexyl]-O-methyl-L-tyros yl-N-[(1S,2S)-4-[[6-[[(4-fluorophenyl)methyl]amino]-6-oxohexyl]amino]-2- hydroxy-1-(2-methylpropyl)-4-oxobutyl]-1-(phenylmethyl)-

Base Information

Chemical Name:L-Histidinamide, N-[6-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxohexyl]-O-methyl-L-tyros yl-N-[(1S,2S)-4-[[6-[[(4-fluorophenyl)methyl]amino]-6-oxohexyl]amino]-2- hydroxy-1-(2-methylpropyl)-4-oxobutyl]-1-(phenylmethyl)-
CAS No.:189163-01-7
Molecular Formula:C55H77FN8O9
Molecular Weight:1013.26
Hs Code.:

L-Histidinamide,
N-[6-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxohexyl]-O-methyl-L-tyros
yl-N-[(1S,2S)-4-[[6-[[(4-fluorophenyl)methyl]amino]-6-oxohexyl]amino]-2-
hydroxy-1-(2-methylpropyl)-4-oxobutyl]-1-(phenylmethyl)-

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Chemical Property of L-Histidinamide, N-[6-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxohexyl]-O-methyl-L-tyros yl-N-[(1S,2S)-4-[[6-[[(4-fluorophenyl)methyl]amino]-6-oxohexyl]amino]-2- hydroxy-1-(2-methylpropyl)-4-oxobutyl]-1-(phenylmethyl)-

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Technology Process of L-Histidinamide, N-[6-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxohexyl]-O-methyl-L-tyros yl-N-[(1S,2S)-4-[[6-[[(4-fluorophenyl)methyl]amino]-6-oxohexyl]amino]-2- hydroxy-1-(2-methylpropyl)-4-oxobutyl]-1-(phenylmethyl)-

There total 13 articles about L-Histidinamide, N-[6-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxohexyl]-O-methyl-L-tyros yl-N-[(1S,2S)-4-[[6-[[(4-fluorophenyl)methyl]amino]-6-oxohexyl]amino]-2- hydroxy-1-(2-methylpropyl)-4-oxobutyl]-1-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1026402-66-3
(S)-2-(6-tert-Butoxycarbonylamino-hexanoylamino)-3-(4-methoxy-phenyl)-propionic acid

: (3S,4S)-4-[(S)-2-Amino-3-(1-benzyl-1H-imidazol-4-yl)-propionylamino]-3-hydroxy-6-methyl-heptanoic acid [5-(4-fluoro-benzylcarbamoyl)-pentyl]-amide

: 189163-01-7
{5-[(S)-1-[(S)-2-(1-Benzyl-1H-imidazol-4-yl)-1-((S)-1-{(S)-2-[5-(4-fluoro-benzylcarbamoyl)-pentylcarbamoyl]-1-hydroxy-ethyl}-3-methyl-butylcarbamoyl)-ethylcarbamoyl]-2-(4-methoxy-phenyl)-ethylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; 1) 0 deg C, 2) r.t., overnight;

Reference yield:

: 6404-29-1
6-(tert-butoxycarbonylamino)hexanoic acid

: 189163-01-7
{5-[(S)-1-[(S)-2-(1-Benzyl-1H-imidazol-4-yl)-1-((S)-1-{(S)-2-[5-(4-fluoro-benzylcarbamoyl)-pentylcarbamoyl]-1-hydroxy-ethyl}-3-methyl-butylcarbamoyl)-ethylcarbamoyl]-2-(4-methoxy-phenyl)-ethylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / HOBt, DCCI / CH₂Cl₂ / 1) 0 deg C, 2) r.t., overnight

2: 1 M NaOH / methanol

3: 21 percent / HOBt, DCCI / CH₂Cl₂ / 1) 0 deg C, 2) r.t., overnight

With sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In methanol; dichloromethane;

Reference yield:

: 58521-49-6
(3S,4S)-4-(tert-butoxycarbonylamino)-3-hydroxy-6-methylheptanoic acid

: 189163-01-7
{5-[(S)-1-[(S)-2-(1-Benzyl-1H-imidazol-4-yl)-1-((S)-1-{(S)-2-[5-(4-fluoro-benzylcarbamoyl)-pentylcarbamoyl]-1-hydroxy-ethyl}-3-methyl-butylcarbamoyl)-ethylcarbamoyl]-2-(4-methoxy-phenyl)-ethylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / HOBt, DCCI / CH₂Cl₂ / 1) 0 deg C, 2) r.t., overnight

2: 4 M HCl / dioxane

3: 48 percent / HOBt, DCCI / CH₂Cl₂ / 1) 0 deg C, 2) r.t., overnight

4: 4 M HCl / dioxane

5: 21 percent / HOBt, DCCI / CH₂Cl₂ / 1) 0 deg C, 2) r.t., overnight

With hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane;