{5-[(S)-1-[(S)-1-((S)-1-{(S)-2-[5-(4-Fluoro-benzylcarbamoyl)-pentylcarbamoyl]-1-hydroxy-ethyl}-3-methyl-butylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-(4-methoxy-phenyl)-ethylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester

Base Information

• Chemical Name: {5-[(S)-1-[(S)-1-((S)-1-{(S)-2-[5-(4-Fluoro-benzylcarbamoyl)-pentylcarbamoyl]-1-hydroxy-ethyl}-3-methyl-butylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-(4-methoxy-phenyl)-ethylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester
• CAS No.: 1053630-07-1
• Molecular Formula: C₄₈H₇₁FN₈O₉
• Molecular Weight: 923.138
• Mol file: 1053630-07-1.mol

Synonyms:{5-[(S)-1-[(S)-1-((S)-1-{(S)-2-[5-(4-Fluoro-benzylcarbamoyl)-pentylcarbamoyl]-1-hydroxy-ethyl}-3-methyl-butylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-(4-methoxy-phenyl)-ethylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester

Chemical Property of {5-[(S)-1-[(S)-1-((S)-1-{(S)-2-[5-(4-Fluoro-benzylcarbamoyl)-pentylcarbamoyl]-1-hydroxy-ethyl}-3-methyl-butylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-(4-methoxy-phenyl)-ethylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {5-[(S)-1-[(S)-1-((S)-1-{(S)-2-[5-(4-Fluoro-benzylcarbamoyl)-pentylcarbamoyl]-1-hydroxy-ethyl}-3-methyl-butylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-(4-methoxy-phenyl)-ethylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester

There total 15 articles about {5-[(S)-1-[(S)-1-((S)-1-{(S)-2-[5-(4-Fluoro-benzylcarbamoyl)-pentylcarbamoyl]-1-hydroxy-ethyl}-3-methyl-butylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-(4-methoxy-phenyl)-ethylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(tert-butoxycarbonylamino)hexanoic acid (6404-29-1) → {5-[(S)-1-[(S)-1-((S)-1-{(S)-2-[5-(4-Fluoro-benzylcarbamoyl)-pentylcarbamoyl]-1-hydroxy-ethyl}-3-methyl-butylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-(4-methoxy-phenyl)-ethylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester (1053630-07-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 73 percent / HOBt, DCCI / CH₂Cl₂ / 1) 0 deg C, 2) r.t., overnight

2: 1 M NaOH / methanol

3: 21 percent / HOBt, DCCI / CH₂Cl₂ / 1) 0 deg C, 2) r.t., overnight

4: H₂ / 5percent PdO/BaSO₄ / methanol; acetic acid; H₂O / 12 h / 1551.4 Torr

With sodium hydroxide; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; barium sulfate; trimethyleneglycol; In methanol; dichloromethane; water; acetic acid;

Reference yield:

{5-[(S)-1-[(S)-2-(1-Benzyl-1H-imidazol-4-yl)-1-((S)-1-{(S)-2-[5-(4-fluoro-benzylcarbamoyl)-pentylcarbamoyl]-1-hydroxy-ethyl}-3-methyl-butylcarbamoyl)-ethylcarbamoyl]-2-(4-methoxy-phenyl)-ethylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester (189163-01-7) → {5-[(S)-1-[(S)-1-((S)-1-{(S)-2-[5-(4-Fluoro-benzylcarbamoyl)-pentylcarbamoyl]-1-hydroxy-ethyl}-3-methyl-butylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-(4-methoxy-phenyl)-ethylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester (1053630-07-1)

Guidance literature:

With hydrogen; barium sulfate; trimethyleneglycol; In methanol; water; acetic acid; for 12h; under 1551.4 Torr;

Reference yield:

O-methyl-N-tert-butoxycarbonyl-L-tyrosine (53267-93-9) → {5-[(S)-1-[(S)-1-((S)-1-{(S)-2-[5-(4-Fluoro-benzylcarbamoyl)-pentylcarbamoyl]-1-hydroxy-ethyl}-3-methyl-butylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-(4-methoxy-phenyl)-ethylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester (1053630-07-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 90 percent / NaHCO₃ / dimethylformamide / 72 h / Ambient temperature

2: 4 M HCl / dioxane

3: 73 percent / HOBt, DCCI / CH₂Cl₂ / 1) 0 deg C, 2) r.t., overnight

4: 1 M NaOH / methanol

5: 21 percent / HOBt, DCCI / CH₂Cl₂ / 1) 0 deg C, 2) r.t., overnight

6: H₂ / 5percent PdO/BaSO₄ / methanol; acetic acid; H₂O / 12 h / 1551.4 Torr

With hydrogenchloride; sodium hydroxide; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; barium sulfate; trimethyleneglycol; In 1,4-dioxane; methanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;

upstream raw materials:

{5-[(S)-1-[(S)-2-(1-Benzyl-1H-imidazol-4-yl)-1-((S)-1-{(S)-2-[5-(4-fluoro-benzylcarbamoyl)-pentylcarbamoyl]-1-hydroxy-ethyl}-3-methyl-butylcarbamoyl)-ethylcarbamoyl]-2-(4-methoxy-phenyl)-ethylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester

6-(tert-butoxycarbonylamino)hexanoic acid

methyl (S)-2-amino-3-(4-methoxyphenyl)propionate

O-methyl-N-tert-butoxycarbonyl-L-tyrosine