D-Proline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycyl-4-(3-benzoyl-3,4-dihydro-5- methyl-2,4-dioxo-1(2H)-pyrimidinyl)-, diphenylmethyl ester, (4R)-

Base Information

Chemical Name:D-Proline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycyl-4-(3-benzoyl-3,4-dihydro-5- methyl-2,4-dioxo-1(2H)-pyrimidinyl)-, diphenylmethyl ester, (4R)-
CAS No.:189163-54-0
Molecular Formula:C47H40N4O8
Molecular Weight:788.857
Hs Code.:

D-Proline,
N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycyl-4-(3-benzoyl-3,4-dihydro-5-
methyl-2,4-dioxo-1(2H)-pyrimidinyl)-, diphenylmethyl ester, (4R)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of D-Proline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycyl-4-(3-benzoyl-3,4-dihydro-5- methyl-2,4-dioxo-1(2H)-pyrimidinyl)-, diphenylmethyl ester, (4R)-

Chemical Property:

Purity/Quality:

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Technology Process of D-Proline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycyl-4-(3-benzoyl-3,4-dihydro-5- methyl-2,4-dioxo-1(2H)-pyrimidinyl)-, diphenylmethyl ester, (4R)-

There total 8 articles about D-Proline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycyl-4-(3-benzoyl-3,4-dihydro-5- methyl-2,4-dioxo-1(2H)-pyrimidinyl)-, diphenylmethyl ester, (4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 86060-85-7
Fmoc-Gly-OPfp

: (2R,4R)-4-(3-Benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pyrrolidine-2-carboxylic acid benzhydryl ester

: 189163-54-0
(2R,4R)-4-(3-Benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-1-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-acetyl]-pyrrolidine-2-carboxylic acid benzhydryl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; Yield given; Ambient temperature;
DOI:10.1039/a603699f

Reference yield:

: 135042-12-5,946610-68-0
(4R)-1-(tert-butoxycarbonyl)-4-hydroxy-D-proline

: 189163-54-0
(2R,4R)-4-(3-Benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-1-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-acetyl]-pyrrolidine-2-carboxylic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / ethyl acetate / Ambient temperature

2: PPh₃, DEAD / tetrahydrofuran / Ambient temperature

3: conc. aq. NH₃ / methanol / 1 h / Ambient temperature

4: 36 percent / PPh₃, DEAD / tetrahydrofuran / Ambient temperature

5: HCl / methanol; tetrahydrofuran / Ambient temperature

6: DIEA / dioxane / Ambient temperature

With hydrogenchloride; ammonium hydroxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; ethyl acetate;
DOI:10.1039/a603699f

Reference yield:

: 4330-20-5
N-3-benzoylthymine

: 189163-54-0
(2R,4R)-4-(3-Benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-1-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-acetyl]-pyrrolidine-2-carboxylic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 36 percent / PPh₃, DEAD / tetrahydrofuran / Ambient temperature

2: HCl / methanol; tetrahydrofuran / Ambient temperature

3: DIEA / dioxane / Ambient temperature

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol;
DOI:10.1039/a603699f