4330-20-5

Basic information

• Product Name: N3-benzoylthymine
• Synonyms: N3-benzoylthymine
• CAS NO: 4330-20-5
• Molecular Formula: C₁₂H₁₀N₂O₃
• Molecular Weight: 230
• Mol File: 4330-20-5.mol
• Article Data: 21

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N3-benzoylthymine(CAS DataBase Reference)
• NIST Chemistry Reference: N3-benzoylthymine(4330-20-5)
• EPA Substance Registry System: N3-benzoylthymine(4330-20-5)

Safety Data

• Hazardous Substances Data: 4330-20-5(Hazardous Substances Data)

Upstream product

• 402848-98-0 tert-butyl 5-methyl-2,4-dioxo-1,2,3,4-tetrahydro pyrimidine-1-carboxylate 
• 98-88-4 benzoyl chloride 
• 65-71-4 thymin 
• 4330-16-9 1,3-dibenzoyl-5-methylpyrimidine-2,4(1H,3H)-dione 
• 100-44-7 benzyl chloride 
• 21473-22-3 3-benzyl-5-methyl-2,4(1H)-pyrimidinedione 

Downstream Products

• 1026490-73-2 [(2S,5R,6S)-5-(3-Benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-6-trityloxymethyl-5,6-dihydro-2H-pyran-2-yl]-phosphonic acid diisopropyl ester 
• 1025825-21-1 [(2R,5R,6S)-5-(3-Benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-6-trityloxymethyl-5,6-dihydro-2H-pyran-2-yl]-phosphonic acid diisopropyl ester 
• 4160-72-9 1-methylthymine 
• 65-71-4 thymin 
• 138903-88-5 methyl cis-3-(3-benzoyl-1,2,3,4-tetrahydro-5-methyl-2,4-dioxopyrimidin-1-yl)cyclopentaneacetate 
• 138903-88-5 [(1R,3S)-3-(3-Benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-cyclopentyl]-acetic acid methyl ester 
• 181935-41-1 3-Benzoyl-1-((1S,2S,4S,5R)-5-benzyloxymethyl-4-tert-butoxy-bicyclo[3.1.0]hex-2-yl)-5-methyl-1H-pyrimidine-2,4-dione 
• 189160-72-3 N-tert-Butoxycarbonyl-N-[2-(N³-benzoylthymin-1-yl)ethyl]glycine methyl ester 
• 168264-26-4 (2S,4R)-4-(3-Benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 168264-15-1 (2S,4S)-4-N³benzoylthymidyl-Boc-prolyl methyl ester 
• 1053648-64-8 3-Benzoyl-1-((3R,5S,6R)-5-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-3-yl)-5-methyl-1H-pyrimidine-2,4-dione 
• 191655-63-7 tert-butyl 7-(N³-benzoylthymin-1-yl)-5S-[N-(tert-butoxycarbonyl)amino]-3-oxaheptanate 

Relevant articles and documents

Novel 1′-homo-: N -2′-deoxy-α-nucleosides: Synthesis, characterization and biological activity

For the first time, a series of novel 1′-homo-N-2′-deoxy-α-nucleosides containing natural nucleobases as well as 5-fluoro and 5-iodopyrimidine analogs have been synthesized in an efficient manner. Additionally, a high yield protocol for the assembly of a dimeric scaffold containing two sugar moieties linked to the N-1 and N-3 positions of a single pyrimidine base has been accomplished. The structures of the novel homonucleosides were established by a single crystal X-ray structure of 1′-homo-N-2′-deoxy-α-adenosine and NMR studies. The biological activity of these 1′-homo-N-2′-deoxy-α-nucleosides as antiviral (HIV-1 and HBV) and cytotoxic studies was measured in multiple cell systems. The unique structure and easy accessibility of these compounds may allow their use in the design of new nucleoside analogs with potential biological activity and as a scaffold for combinatorial chemistry.

CYCLOPENTYL NUCLEOSIDE ANALOGS AS ANTI-VIRALS

Described herein are cyclopentyl nucleoside analogs, pharmaceutical compositions that include one or more cyclopentyl nucleoside analogs and methods of using the same to treat HBV, HDV and/or HIV.

Synthesis of 5,5-difluoro-5-phosphono-pent-2-en-1-yl nucleosides as potential antiviral agents

A series of hitherto unknown acyclic 5,5-difluoro-5-phosphono-pent-2-en-1-yl-pyrimidines (9a, b, 13a, b), -purines (16a, b) and -(1,2,4)-triazolo-3-carboxamide (19) were successfully synthesized from (E)-1-bromo-5-diethoxyphosphoryl-5,5-difluoro-pent-2-en