Thymidine, 5'-deoxy-5'-oxo-3-(phenylmethyl)-3'-O-2-propenyl-

Base Information

Chemical Name:Thymidine, 5'-deoxy-5'-oxo-3-(phenylmethyl)-3'-O-2-propenyl-
CAS No.:189265-54-1
Molecular Formula:C20H22N2O5
Molecular Weight:370.405
Hs Code.:

Synonyms:

Suppliers and Price of Thymidine, 5'-deoxy-5'-oxo-3-(phenylmethyl)-3'-O-2-propenyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Thymidine, 5'-deoxy-5'-oxo-3-(phenylmethyl)-3'-O-2-propenyl-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Thymidine, 5'-deoxy-5'-oxo-3-(phenylmethyl)-3'-O-2-propenyl-

There total 6 articles about Thymidine, 5'-deoxy-5'-oxo-3-(phenylmethyl)-3'-O-2-propenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 189265-53-0
3'-O-allyl-N³-benzyl thymidine

: 189265-54-1
3-allyloxy-2-formyl-5-(N³-benzyl thymin-1-yl)-tetrahydrofuran

Guidance literature:: 3'-O-allyl-N³-benzyl thymidine; With pyridine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dimethyl sulfoxide; benzene; at 20 ℃; for 18h;

With oxalic acid; In methanol; dimethyl sulfoxide; benzene; for 0.5h;
DOI:10.1016/S0040-4020(97)00141-5

Reference yield:

: 7791-71-1
5'-O-tritylthymidine

: 189265-54-1
3-allyloxy-2-formyl-5-(N³-benzyl thymin-1-yl)-tetrahydrofuran

Guidance literature:: Multi-step reaction with 6 steps

1.1: 95 percent / pyridine / 14 h / 10 °C

2.1: sodium hydride / dimethylformamide / 1 h / 0 °C

2.2: 92 percent / dimethylformamide / 5 h / 20 °C

3.1: 98 percent / sodium methoxide / methanol / 5 h / 0 °C

4.1: 92 percent / NaOH; tetrabutylammonium bromide / CH₂Cl₂; H₂O / 20 h / 20 °C

5.1: 70 percent / acetic acid; water / 5 h / 80 °C

6.1: pyridine; trifluoroacetic acid; DCC / dimethylsulfoxide; benzene / 18 h / 20 °C

6.2: 69 percent / oxalic acid / dimethylsulfoxide; benzene; methanol / 0.5 h

With pyridine; sodium hydroxide; tetrabutylammomium bromide; water; sodium methylate; sodium hydride; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; In methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; benzene; 1.1: Acetylation / 2.1: Metallation / 2.2: benzylation / 3.1: Deacetylation / 4.1: allylation / 5.1: detritylation / 6.1: Moffatt oxidation / 6.2: Moffatt oxidation;
DOI:10.1016/S0040-4020(97)00141-5

Reference yield:

: 23583-46-2
3'-O-acetyl-5'-O-triphenylmethylthymidine

: 189265-54-1
3-allyloxy-2-formyl-5-(N³-benzyl thymin-1-yl)-tetrahydrofuran

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / dimethylformamide / 1 h / 0 °C

1.2: 92 percent / dimethylformamide / 5 h / 20 °C

2.1: 98 percent / sodium methoxide / methanol / 5 h / 0 °C

3.1: 92 percent / NaOH; tetrabutylammonium bromide / CH₂Cl₂; H₂O / 20 h / 20 °C

4.1: 70 percent / acetic acid; water / 5 h / 80 °C

5.1: pyridine; trifluoroacetic acid; DCC / dimethylsulfoxide; benzene / 18 h / 20 °C

5.2: 69 percent / oxalic acid / dimethylsulfoxide; benzene; methanol / 0.5 h

With pyridine; sodium hydroxide; tetrabutylammomium bromide; water; sodium methylate; sodium hydride; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; In methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; benzene; 1.1: Metallation / 1.2: benzylation / 2.1: Deacetylation / 3.1: allylation / 4.1: detritylation / 5.1: Moffatt oxidation / 5.2: Moffatt oxidation;
DOI:10.1016/S0040-4020(97)00141-5