23583-46-2

Basic information

• Product Name: 1-(3-O-acetyl-2-deoxy-5-O-tritylpentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
• CAS NO: 23583-46-2
• Molecular Formula: C₃₁H₃₀N₂O₆
• Molecular Weight: 526.5797
• Mol File: 23583-46-2.mol
• Article Data: 2

Chemical Properties

• Density: 1.31g/cm³
• Refractive Index: 1.643
• CAS DataBase Reference: 1-(3-O-acetyl-2-deoxy-5-O-tritylpentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-O-acetyl-2-deoxy-5-O-tritylpentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione(23583-46-2)
• EPA Substance Registry System: 1-(3-O-acetyl-2-deoxy-5-O-tritylpentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione(23583-46-2)

Safety Data

• Hazardous Substances Data: 23583-46-2(Hazardous Substances Data)

Usage

General Description

1-(3-O-acetyl-2-deoxy-5-O-tritylpentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione is a chemical compound with a complex structure. It contains a pentofuranosyl group, an acetyl group, and a trityl group, as well as a pyrimidine-2,4(1H,3H)-dione moiety. 1-(3-O-acetyl-2-deoxy-5-O-tritylpentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione is a derivative of thymidine, a nucleoside that is a structural component of DNA. The presence of the acetyl and trityl groups suggests that this compound may be used for chemical synthesis or as a precursor to other compounds. Its specific properties and potential uses would depend on the context in which it is being studied or utilized.

Upstream product

• 76-83-5 trityl chloride 
• 108-24-7 acetic anhydride 
• 7791-71-1 5'-O-tritylthymidine 

Downstream Products

• 519-73-3 triphenylmethane 
• 5333-62-0 benzyl trityl ether 
• 21090-30-2 3'-O-acetylthymidine 
• 65-71-4 thymin 
• 365-07-1 thymidine 5'-phosphate 
• 189265-52-9 3'-O-allyl-N³-benzyl-5'-O-trityl thymidine 
• 189265-51-8 N³-benzyl-5'-O-trityl thymidine 
• 189265-55-2 9-benzyl-2-[N³-benzyl-5-methyl-2,4(1H,3H)-pyrimidinedion-1-yl]-perhydro-6,8-(epoxyimino)furo[3,2-b]oxepin 
• 189265-53-0 3'-O-allyl-N³-benzyl thymidine 
• 189265-54-1 3-allyloxy-2-formyl-5-(N³-benzyl thymin-1-yl)-tetrahydrofuran 
• 189265-50-7 3'-O-acetyl-N³-benzyl-5'-O-trityl thymidine 

Relevant articles and documents

Exploring the potential of 3′-O-carboxy esters of thymidine as inhibitors of ribonuclease A and angiogenin

In this study, compounds with a carboxy ester in lieu of the phosphate ester at the 3′-position have been employed to inhibit the ribonucleolytic activity of ribonuclease A (RNase A). Phosphates at the 3′-position of pyrimidine bases are well-known inhibitors of the protein. We have investigated the inhibition of RNase A by 3′-O-carboxy esters of thymidine. The compounds behave as competitive inhibitors with inhibition constants ranging from 42 to 95 μM. The mode of inhibition has also been confirmed by 1H NMR studies of the active site histidines of RNase A. Docking studies have further substantiated the experimental results. The compounds are also found to inhibit the ribonucleolytic activity of angiogenin, a homologous protein and potent inducer of blood vessel formation.