Benzamide, 4-[3-[[[1-[2,4-dichloro-3-[[(methylsulfonyl)oxy]methyl]phenyl]-1H-pyrrol-2- yl]methyl]amino]-3-oxo-1-propenyl]-N,N-dimethyl-, (E)-

Base Information

Chemical Name:Benzamide, 4-[3-[[[1-[2,4-dichloro-3-[[(methylsulfonyl)oxy]methyl]phenyl]-1H-pyrrol-2- yl]methyl]amino]-3-oxo-1-propenyl]-N,N-dimethyl-, (E)-
CAS No.:189268-92-6
Molecular Formula:C25H25Cl2N3O5S
Molecular Weight:550.463
Hs Code.:

Synonyms:

Suppliers and Price of Benzamide, 4-[3-[[[1-[2,4-dichloro-3-[[(methylsulfonyl)oxy]methyl]phenyl]-1H-pyrrol-2- yl]methyl]amino]-3-oxo-1-propenyl]-N,N-dimethyl-, (E)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Benzamide, 4-[3-[[[1-[2,4-dichloro-3-[[(methylsulfonyl)oxy]methyl]phenyl]-1H-pyrrol-2- yl]methyl]amino]-3-oxo-1-propenyl]-N,N-dimethyl-, (E)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Benzamide, 4-[3-[[[1-[2,4-dichloro-3-[[(methylsulfonyl)oxy]methyl]phenyl]-1H-pyrrol-2- yl]methyl]amino]-3-oxo-1-propenyl]-N,N-dimethyl-, (E)-

There total 6 articles about Benzamide, 4-[3-[[[1-[2,4-dichloro-3-[[(methylsulfonyl)oxy]methyl]phenyl]-1H-pyrrol-2- yl]methyl]amino]-3-oxo-1-propenyl]-N,N-dimethyl-, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 167837-45-8
3-amino-1-(tert-butyldiphenylsilyloxymethyl)-2,6-dichlorobenzene

: 189268-92-6
Methanesulfonic acid 2,6-dichloro-3-(2-{[(E)-3-(4-dimethylcarbamoyl-phenyl)-acryloylamino]-methyl}-pyrrol-1-yl)-benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 85.9 percent / acetic acid / 1 h / 90 °C

2.1: CH₂Cl₂ / 1.5 h

2.2: 73.6 percent / DMF / CH₂Cl₂ / 1.5 h / -20 - 20 °C

3.1: 50.2 percent / lithium aluminum hydride / tetrahydrofuran / 1 h

4.1: 100 percent / 1-ethoxy-3-[3-(dimethylamino)propyl]carbodiimide*HCl; 1-hydroxybenzotriazole / dimethylformamide / 3 h

5.1: 100 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h

6.1: Et₃N / CH₂Cl₂ / 0.5 h / cooling

With lithium aluminium tetrahydride; 1-(3-dimethylaminopropyl)-3-ethoxycarbodiimide hydrochloride; tetrabutyl ammonium fluoride; benzotriazol-1-ol; triethylamine; In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm030159x

Reference yield:

: 189268-25-5
1-[3-(tert-butyldiphenylsilyloxymethyl)-2,4-dichlorophenyl]pyrrole

: 189268-92-6
Methanesulfonic acid 2,6-dichloro-3-(2-{[(E)-3-(4-dimethylcarbamoyl-phenyl)-acryloylamino]-methyl}-pyrrol-1-yl)-benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: CH₂Cl₂ / 1.5 h

1.2: 73.6 percent / DMF / CH₂Cl₂ / 1.5 h / -20 - 20 °C

2.1: 50.2 percent / lithium aluminum hydride / tetrahydrofuran / 1 h

3.1: 100 percent / 1-ethoxy-3-[3-(dimethylamino)propyl]carbodiimide*HCl; 1-hydroxybenzotriazole / dimethylformamide / 3 h

4.1: 100 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h

5.1: Et₃N / CH₂Cl₂ / 0.5 h / cooling

With lithium aluminium tetrahydride; 1-(3-dimethylaminopropyl)-3-ethoxycarbodiimide hydrochloride; tetrabutyl ammonium fluoride; benzotriazol-1-ol; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030159x

Reference yield:

: 189268-26-6
1-[3-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,4-dichlorophenyl]-1H-pyrrole-2-carbonitrile

: 189268-92-6
Methanesulfonic acid 2,6-dichloro-3-(2-{[(E)-3-(4-dimethylcarbamoyl-phenyl)-acryloylamino]-methyl}-pyrrol-1-yl)-benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 50.2 percent / lithium aluminum hydride / tetrahydrofuran / 1 h

2: 100 percent / 1-ethoxy-3-[3-(dimethylamino)propyl]carbodiimide*HCl; 1-hydroxybenzotriazole / dimethylformamide / 3 h

3: 100 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h

4: Et₃N / CH₂Cl₂ / 0.5 h / cooling

With lithium aluminium tetrahydride; 1-(3-dimethylaminopropyl)-3-ethoxycarbodiimide hydrochloride; tetrabutyl ammonium fluoride; benzotriazol-1-ol; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030159x