Benzamide, 4-[(1E)-3-[[[3-[3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-2,4-dimeth ylphenyl]-2-thienyl]methyl]amino]-3-oxo-1-propenyl]-N-methyl-

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Chemical Name:Benzamide, 4-[(1E)-3-[[[3-[3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-2,4-dimeth ylphenyl]-2-thienyl]methyl]amino]-3-oxo-1-propenyl]-N-methyl-
CAS No.:189269-12-3
Molecular Formula:C41H44N2O3SSi
Molecular Weight:672.963
Hs Code.:

Benzamide,
4-[(1E)-3-[[[3-[3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-2,4-dimeth
ylphenyl]-2-thienyl]methyl]amino]-3-oxo-1-propenyl]-N-methyl-

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Chemical Property of Benzamide, 4-[(1E)-3-[[[3-[3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-2,4-dimeth ylphenyl]-2-thienyl]methyl]amino]-3-oxo-1-propenyl]-N-methyl-

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Technology Process of Benzamide, 4-[(1E)-3-[[[3-[3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-2,4-dimeth ylphenyl]-2-thienyl]methyl]amino]-3-oxo-1-propenyl]-N-methyl-

There total 5 articles about Benzamide, 4-[(1E)-3-[[[3-[3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-2,4-dimeth ylphenyl]-2-thienyl]methyl]amino]-3-oxo-1-propenyl]-N-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 189269-11-2
2-aminomethyl-3-(3-tert-butyldiphenylsilyloxymethyl-2,4-dimethylphenyl)thiophene

: 179627-11-3
4-(methylcarbamoyl)cinnamic acid

: 189269-12-3
3-(3-tert-Butyldiphenylsilyloxymethyl-2,4-dimethylphenyl)-2-[4-(methylcarbamoyl)cinnamoylaminomethyl]-thiophene

Guidance literature:: With WSCD*HCl; benzotriazol-1-ol; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2.5h;
DOI:10.1021/jm980330i

Reference yield:

: 18791-98-5
3-bromo-thiophene-2-carbonitrile

: 189269-12-3
3-(3-tert-Butyldiphenylsilyloxymethyl-2,4-dimethylphenyl)-2-[4-(methylcarbamoyl)cinnamoylaminomethyl]-thiophene

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-butyllithium, 2.) ZnCl₂, 3.) tetrakis(triphenylphosphine)palladium⁽⁰⁾

2: 1.) BF₃, 2.) 1 N aq. HCl / 1.) THF, RT, 14 h, 2.) THF, RT, 1 h

3: HOBt, WSCD*HCl / dimethylformamide / 2.5 h / 0 - 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; WSCD*HCl; boron trifluoride; benzotriazol-1-ol; zinc(II) chloride; In N,N-dimethyl-formamide;
DOI:10.1021/jm980330i

Reference yield:

: 1-tert-butyldiphenylsilyloxymethyl-2,6-dimethyl-3-bromobenzene

: 189269-12-3
3-(3-tert-Butyldiphenylsilyloxymethyl-2,4-dimethylphenyl)-2-[4-(methylcarbamoyl)cinnamoylaminomethyl]-thiophene

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-butyllithium, 2.) ZnCl₂, 3.) tetrakis(triphenylphosphine)palladium⁽⁰⁾

2: 1.) BF₃, 2.) 1 N aq. HCl / 1.) THF, RT, 14 h, 2.) THF, RT, 1 h

3: HOBt, WSCD*HCl / dimethylformamide / 2.5 h / 0 - 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; WSCD*HCl; boron trifluoride; benzotriazol-1-ol; zinc(II) chloride; In N,N-dimethyl-formamide;
DOI:10.1021/jm980330i