Androstan-3-one

Base Information

• Chemical Name: Androstan-3-one
• CAS No.: 1224-95-9
• Molecular Formula: C19H30 O
• Molecular Weight: 274.447
• Mol file: 1224-95-9.mol

Synonyms:5a-Androstan-3-one (6CI,7CI,8CI);NSC 50893

Chemical Property of Androstan-3-one

Chemical Property:

• Vapor Pressure: 1.27E-05mmHg at 25°C
• Melting Point: 103-104 °C
• Boiling Point: 368.5°Cat760mmHg
• Flash Point: 168.7°C
• PSA: 17.07000
• Density: 1.014g/cm³
• LogP: 4.98830

Purity/Quality:

99%, ^*data from raw suppliers

5alpha-Androstan-3-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Androstan-3-one

There total 20 articles about Androstan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5α-androstan-3β-ol (1224-93-7,7657-50-3,7753-89-1,10085-14-0,15360-52-8,15360-53-9,36216-01-0,36216-02-1,1224-92-6) → androstan-3-one (1224-95-9,118371-41-8)

Guidance literature:

With silica gel; pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 2h;

Reference yield: 18.0%

(5S,8S,9S,10S,13S,14S)-10,13-dimethyl-4,5,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one (3248-10-0) → androstan-3-one (1224-95-9,118371-41-8) + 5(10-> 1)abeo-5α,10α-androst-1-en-3-one (88147-12-0) + 1-methyl-19-nor-5α,10ξ-androst-1-en-3-one + 5(10-> 1)abeo-5α-androst-1-en-3-one

Guidance literature:

With sulfuric acid; Irradiation;

DOI:10.1039/c39830000718

Reference yield: 16.0%

(5S,8S,9S,10S,13S,14S)-10,13-dimethyl-4,5,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one (3248-10-0) → androstan-3-one (1224-95-9,118371-41-8) + 1-methyl-5α,10α-estr-1-en-3-one (113890-45-2)

Guidance literature:

With sulfuric acid; at 45 ℃; for 48h; Product distribution; Mechanism; var. reaction conditions;

DOI:10.1021/jo00245a013

upstream raw materials:

5α-androstan-3β-ol

5α-androst-16-en-3-one

17-semicarbazone of 3β-hydroxyandrost-5-en-17-one

sodium ethanolate

Downstream raw materials:

3,3-Aethylendioxy-5α-androstan

5α-Androstan-3-spiro-2'-thiazolidin

(5S,8S,9S,10S,13S,14S)-10,13-dimethyl-4,5,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one

4-androsten-3-one

Refernces

• 1、 -. "HUMAN GHRELIN O-ACYL TRANSFERASE INHIBITORS". Paragraph 0052-0054. . Retrieved 2018/03/09.
• 2、 Jursic, Branko S.,Upadhyay, Sunil Kumar,Creech, Clinton C.,Neumann, Donna M.. "Novel and efficient synthesis and antifungal evaluation of 2,3-functionalized cholestane and androstane derivatives". supporting information; experimental part. p. 7372 - 7375. Retrieved 2011/02/23.