Sodium ethoxide

Base Information

• Chemical Name: Sodium ethoxide
• CAS No.: 141-52-6
• Deprecated CAS: 24448-24-6,1628390-26-0
• Molecular Formula: C2H5NaO
• Molecular Weight: 68.0509
• Hs Code.: 2905.19
• European Community (EC) Number: 205-487-5
• ICSC Number: 0674
• UNII: 1I9504387J
• DSSTox Substance ID: DTXSID3027089
• Nikkaji Number: J91.259J
• Wikipedia: Sodium ethoxide
• Wikidata: Q412779
• Mol file: 141-52-6.mol

Synonyms:sodium ethoxide

Chemical Property of Sodium ethoxide

Chemical Property:

• Appearance/Colour: White to pale brown solid
• Vapor Pressure: <0.1 mm Hg ( 20 °C)
• Melting Point: 260 °C
• Refractive Index: n20/D 1.386
• Boiling Point: 72.6 °C at 760 mmHg
• Flash Point: 8.9 °C
• PSA: 23.06000
• Density: 0.868 g/mL at 25 °C
• LogP: 0.43680
• Storage Temp.: Store at R.T.
• Sensitive.: Moisture Sensitive
• Solubility.: Soluble in ethanol and methanol.
• Water Solubility.: Miscible
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 68.02380906
• Heavy Atom Count: 4
• Complexity: 6

Purity/Quality:

≥99% ^*data from raw suppliers

Sodium ethoxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,C,Xi
• Hazard Codes: F,C,Xi,N
• Statements: 11-14-34-36/37/38-68/20/21/22-51/53-20/21/22
• Safety Statements: 8-16-26-43-45-36/37/39-36-61

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Metals -> Metal Alkoxides
• Canonical SMILES: CC[O-].[Na+]
• Inhalation Risk: A harmful concentration of airborne particles can be reached quickly when dispersed.
• Effects of Short Term Exposure: Corrosive.
• Physical properties: White or yellowish powder; hygroscopic; darkens and decomposes on exposure to air; decomposes in water forming sodium hydroxide and ethanol; dissolves in absolute ethanol.
• Uses: Sodium ethoxide is used in organic synthesis for condensation reactions. It also is a catalyst in many organic reactions. Sodium ethoxide, 21% w/w in ethanol is used as a strong base in organic synthesis. It finds application in various chemical reactions such as condensation, esterification, alkoxylation and etherifcation. It is actively involved in Claisen condensation, Stobbe reaction and Wolf-kishner reduction. It is an important starting material for the synthesis of ethyl ester and diethyl ester of malonic acid. In Williamson ether synthesis, it reacts with ethyl bromide to form diethyl ether.

Technology Process of Sodium ethoxide

There total 157 articles about Sodium ethoxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

phenythoin (57-41-0) + ethyl bromoacetate (105-36-2) → ethyl 2-(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)acetate (976-85-2) + sodium ethanolate (141-52-6)

Guidance literature:

In ethanol;

Reference yield: 84.0%

oxalic acid diethyl ester (95-92-1) → spiro [4H-1-benzopyran-4,2'-pyrrolidine]3'-carboxylic acid + sodium ethanolate (141-52-6)

Guidance literature:

With sodium; In ethanol;

Reference yield: 48.0%

3-cyclohexene-1-chloromethane + diethyl malonate (105-53-3) → sodium ethanolate (141-52-6)

Guidance literature:

In diethyl ether; ethanol; water;

upstream raw materials:

diethyl ether

isopentyl sodium

ethyl sodium

ethanol

Downstream raw materials:

4-quinolinic acid

6β-chloro-6-deoxycodeine

2-(2-cyanophenoxy)ethyl alcohol

2-(4-nitrophenoxy)ethanol

Refernces

• 1、 Kabatas, Selda,Vreja, Ingrid C.,Saka, Sinem K.,H?schen, Carmen,Kr?hnert, Katharina,Opazo, Felipe,Rizzoli, Silvio O.,Diederichsen, Ulf. "A contamination-insensitive probe for imaging specific biomolecules by secondary ion mass spectrometry". . p. 13221 - 13224. Retrieved 2015.
• 2、 Shah, Reem,Habeebullah, Turki M.,Saad, Fawaz,Althagafi, Ismail,Al-dawood, Aisha Y.,Al-Solimy, Amerah M.,Al-Ahmed, Zehba A.,Al-Zahrani, Fatimah,Farghaly, Thoraya A.,El-Metwaly, Nashwa. "Characterization of new Co(II) complexes and photographic monitoring for their toxic impact on breast cancer cells according to simulation study". . . Retrieved 2020.
• 3、 Wan, Yupeng,Lyu, Heng,Du, Hengyi,Wang, Dunjia,Yin, Guodong. "Synthesis and photophysical properties of europium pentafluorinated β-diketonate complexes". . p. 1669 - 1687. Retrieved 2019.
• 4、 Ford, Leigh,Harjani, Jitendra R.,Atefi, Farzad,Garcia, M. Teresa,Singer, Robert D.,Scammells, Peter J.. "Further studies on the biodegradation of ionic liquids". . p. 1783 - 1789. Retrieved 2010.
• 5、 Badio, Barbara,Garraffo, H. Martin,Plummer, Carlton V.,Padgett, William L.,Daly, John W.. "Synthesis and nicotinic activity of epiboxidine: An isoxazole analogue of epibatidine". . p. 189 - 194. Retrieved 1997.
• 6、 Eagle, S.,Warner, J. C.. "". . p. 488 - 495. Retrieved 1939.
• 7、 Petrus, Rafa?,Dr?g-Jarz?bek, Anna,Utko, Józef,Bykowski, Dominik,Lis, Tadeusz,Sobota, Piotr. "Molecular Routes to Group IV Magnesium and Calcium Nanocrystalline Ceramics". . p. 11365 - 11374. Retrieved 2017.
• 8、 -. "Catalyst system for producing polyethylene copolymers in a high temperature solution polymerization process". . . Retrieved 2022/03/27.