L-Glutamic acid, N-[4-[4-[[2-[(2,2-dimethyl-1-oxopropyl)amino]-5-[(hydroxyimino)methyl]- 6-methoxy-4-pyrimidinyl](phenylmethyl)amino]-1-butynyl]benzoyl]-, diethyl ester

Base Information

Chemical Name:L-Glutamic acid, N-[4-[4-[[2-[(2,2-dimethyl-1-oxopropyl)amino]-5-[(hydroxyimino)methyl]- 6-methoxy-4-pyrimidinyl](phenylmethyl)amino]-1-butynyl]benzoyl]-, diethyl ester
CAS No.:189383-77-5
Molecular Formula:C38H46N6O8
Molecular Weight:714.819
Hs Code.:

L-Glutamic acid,
N-[4-[4-[[2-[(2,2-dimethyl-1-oxopropyl)amino]-5-[(hydroxyimino)methyl]-
6-methoxy-4-pyrimidinyl](phenylmethyl)amino]-1-butynyl]benzoyl]-,
diethyl ester

Synonyms:

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Glutamic acid, N-[4-[4-[[2-[(2,2-dimethyl-1-oxopropyl)amino]-5-[(hydroxyimino)methyl]- 6-methoxy-4-pyrimidinyl](phenylmethyl)amino]-1-butynyl]benzoyl]-, diethyl ester

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of L-Glutamic acid, N-[4-[4-[[2-[(2,2-dimethyl-1-oxopropyl)amino]-5-[(hydroxyimino)methyl]- 6-methoxy-4-pyrimidinyl](phenylmethyl)amino]-1-butynyl]benzoyl]-, diethyl ester

There total 3 articles about L-Glutamic acid, N-[4-[4-[[2-[(2,2-dimethyl-1-oxopropyl)amino]-5-[(hydroxyimino)methyl]- 6-methoxy-4-pyrimidinyl](phenylmethyl)amino]-1-butynyl]benzoyl]-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 189383-75-3
diethyl 4-{[4-N-benzyl-(5-formyl-6-methoxy-2-pivaloylaminopyrimidin-4-yl)amino]but-1-ynyl}-benzoyl-L-glutamate

: 189383-77-5
diethyl 4-{[4-N-benzyl-(6-methoxy-5-oximinomethyl-2-pivaloylaminopyrimidin-4-yl)amino]but-1-ynyl}-benzoyl-L-glutamate

Guidance literature:: With pyridine; hydroxylamine hydrochloride; In ethanol; for 5h; Ambient temperature;

Reference yield:

: 116387-21-4
4-iodobenzoyl-L-glutamic acid diethyl ester

: 189383-77-5
diethyl 4-{[4-N-benzyl-(6-methoxy-5-oximinomethyl-2-pivaloylaminopyrimidin-4-yl)amino]but-1-ynyl}-benzoyl-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1: 58 percent / triphenylphosphine, copper(I) iodide, triethylamine / palladium chloride / acetonitrile / 5 h / Heating

2: 93 percent / hydroxylamine hydrochloride, pyridine / ethanol / 5 h / Ambient temperature

With pyridine; copper(l) iodide; hydroxylamine hydrochloride; triethylamine; triphenylphosphine; palladium dichloride; In ethanol; acetonitrile;

Reference yield:

: 178392-69-3
N-[4-(Benzyl-but-3-ynyl-amino)-5-formyl-6-methoxy-pyrimidin-2-yl]-2,2-dimethyl-propionamide

: 189383-77-5
diethyl 4-{[4-N-benzyl-(6-methoxy-5-oximinomethyl-2-pivaloylaminopyrimidin-4-yl)amino]but-1-ynyl}-benzoyl-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1: 58 percent / triphenylphosphine, copper(I) iodide, triethylamine / palladium chloride / acetonitrile / 5 h / Heating

2: 93 percent / hydroxylamine hydrochloride, pyridine / ethanol / 5 h / Ambient temperature

With pyridine; copper(l) iodide; hydroxylamine hydrochloride; triethylamine; triphenylphosphine; palladium dichloride; In ethanol; acetonitrile;