178392-69-3

Upstream product

• 1538-75-6 2,2-dimethylpropanoic anhydride 
• 178392-68-2 2-amino-6-(N-benzyl-N-3-butynylamino)-5-formyl-4-methoxypyrimidine 
• 100-52-7 benzaldehyde 
• 107301-61-1 N-benzyl-4-amino-1-butyne 
• 178392-67-1 2-amino-6-(N-benzyl-N-3-butynylamino)-4-chloro-5-formylpyrimidine 

Downstream Products

• 189383-81-1 diethyl 4-[(6-benzyl-10(9H)-oxo-8-pivaloylamino)-4,5-dihydro-6H-isoxazolo[3,4-d]pyrimido[4,5-b]azepin-3-yl]benzoyl-L-glutamate 
• 189383-79-7 diethyl 4-[(6-benzyl-10-methoxy-8-pivaloylamino)-4,5-dihydro-6H-isoxazolo[3,4-d]pyrimido[4,5-b]azepin-3-yl] benzoyl-L-glutamate 
• 189383-77-5 diethyl 4-{[4-N-benzyl-(6-methoxy-5-oximinomethyl-2-pivaloylaminopyrimidin-4-yl)amino]but-1-ynyl}-benzoyl-L-glutamate 
• 189383-75-3 diethyl 4-{[4-N-benzyl-(5-formyl-6-methoxy-2-pivaloylaminopyrimidin-4-yl)amino]but-1-ynyl}-benzoyl-L-glutamate 

Relevant academic research and scientific papers

Synthesis of 5-amino-9-benzyl-6-formyl-4-methoxy-2-pivaloylamino-7,8-dihydropyrimido[4,5-b] azepine. A potentially useful intermediate towards the synthesis of pyrimidoazepine based folic acid derivatives

Synthesis of the title compound is described via an intramolecular 1,3-dipolar cycloaddition reaction between the pyrimidine nitrile oxide 24 and an alkyne dipolarophile tethered to the 6-position of the pyrimidine ring. The resulting isoxazolopyrimidoaze