N-DESMETHYL ZOPICLONE

Base Information

• Chemical Name: N-DESMETHYL ZOPICLONE
• CAS No.: 59878-63-6
• Molecular Formula: C₁₆H₁₅ClN₆O₃
• Molecular Weight: 374.786
• Mol file: 59878-63-6.mol

Synonyms:5H-Pyrrolo[3,4-b]pyrazine,1-piperazinecarboxylic acid deriv.; Desmethylzopiclone; N-Demethylzopiclone;N-Desmethyl zopiclone; Norzopiclone; RP 32273

Chemical Property of N-DESMETHYL ZOPICLONE

Chemical Property:

• Vapor Pressure: 2.61E-14mmHg at 25°C
• Melting Point: 226-2280C
• Boiling Point: 599°C at 760 mmHg
• PKA: 8.26±0.10(Predicted)
• Flash Point: 316.1°C
• PSA: 100.55000
• Density: 1.57g/cm³
• LogP: 2.35950
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly), Water (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

N-Desmethylzopiclone solution 100?μg/mL in acetonitrile, certified reference material, Cerilliant? ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Desmethyl Zopiclone is a metabolite of Zopiclone (Z700500), N-Desmethyl Zopiclone is an intermediate in the synthesis of N-Desmethyl Zopiclone Hydrochloride (D296770).

Technology Process of N-DESMETHYL ZOPICLONE

There total 2 articles about N-DESMETHYL ZOPICLONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

zopiclon (43200-80-2) → N-Desmethylzopiclone (59878-63-6,151776-26-0)

Guidance literature:

In acetonitrile; for 0.5h; pH=9.5; pH-value; Electrochemical reaction;

DOI:10.1007/s00706-015-1602-9

Reference yield:

→ N-Desmethylzopiclone (59878-63-6,151776-26-0)

Guidance literature:

Entspr. ROCO2C6H5, Amin;

Reference yield:

N-succinimidyl-3-(p-hydroxyphenyl)propionate (34071-95-9) + N-Desmethylzopiclone (59878-63-6,151776-26-0) → desmethylzopiclone-N-<3-(4-hydroxyphenyl)-propionamide>

Guidance literature:

In 1,4-dioxane; for 6h; Ambient temperature;

DOI:10.1002/jlcr.2580340311

upstream raw materials:

zopiclon