43200-80-2 Usage
Description
Different sources of media describe the Description of 43200-80-2 differently. You can refer to the following data:
1. Zopiclone is an agonist at the type A γ-aminobutyric acid (GABA) receptor. It is a non-benzodiazepine hypnotic which was first reviewed in Drugs in 1986 and it is indicated for short-term treatment of insomnia. Zopiclone has a relatively low propensity to cause residual clinical effects (such as difficulty in waking or reduced morning concentration).
2. Zopiclone is an effective hypnotic agent with a short duration of action. Although
it interacts with the benzodiazepine receptor
complex, it is reported to have minimal effects on memory, little synergy with alcohol, and low abuse potential.
References
[1] Stuart Noble, Heather D. Langtry and Harriet M. Lamb, Drugs, 1998, vol. 55, 277-302
[2] G. Hajak, W. E. Müller, H. U. Wittchen, D. Pittrow, W. Kirch, Abuse and dependence potential for the non-benzodiazepine hypnotics zolpidem and zopiclone: a review of case reports and epidemiological data, Addiction, 2003, vol. 98, 1371-1378
Chemical Properties
Crystalline Solid
Uses
Different sources of media describe the Uses of 43200-80-2 differently. You can refer to the following data:
1. antihyperammonemic,antineoplastic
2. inhibits tyrosinase and prevents melanin formation used to whiten and lighten skin
3. Cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists. This is a controlled substance (depressant) in the US but not in Canada. Sedative, hypnotic
Definition
ChEBI: A pyrrolo[3,4-b]pyrazine compound having a 4-methylpiperazine-1-carboxyl group at the 5-position, a 5-chloropyridin-2-yl group at the 6-position and an oxo-substituent at the 7-position.
Manufacturing Process
Producing of 6-(5-chloropyrid-2-yl)-5-(4-methylpiperazin-1-yl)-carbonyloxy-7-
oxo-5,6-dihydropyrrolo[3,4-b]pyrazine by two methods.
1). A solution of 6-(5-chloropyrid-2-yl)-5-hydroxy-7-oxo-5,6-
dihydropyrrolo[3,4-b]pyrazine (12.0 g) in anhydrous dimethylformamide (360
ml) is added to a suspension of sodium hydride (50% dispersion in mineral
oil) (2.4 g) in anhydrous dimethylformamide (60 ml), whilst maintaining the
temperature at about -10°C. When the evolution of gas has ceased, a solution
of 1-chlorocarbonyl-4-methylpiperazine (8.1 g) in anhydrous
dimethylformamide (20 ml) is added, whilst maintaining the temperature at
about -10°C. The reaction mixture is stirred for a further 3 h whilst allowing it
to heat up gradually to a temperature of about 20°C, and then it is poured
into ice-water (1540 ml). The product which crystallizes is filtered off, washed
with water (150 ml) and then with diisopropyl ether (100 ml). After drying, a
product is obtained and is dissolved in ethyl acetate (600 ml). The solution
obtained is filtered through silica gel (250.0 g). Elution is then carried out with
ethyl acetate (3200 ml) followed by a mixture of ethyl acetate and methanol
The eluates are combined and concentrated to dryness under reduced
pressure. So 8.3 g of the 6-(5-chloropyrid-2-yl)-5-(4-methylpiperazin-1-yl)-
carbonyloxy-7-oxo-5,6-dihydropyrrolo[3,4-b]pyrazine are obtained, melting
point 178°C (recrystallisation from a mixture of acetonitrile and diisopropyl
ether 1:1; 190 ml).
2). 1-Methylpiperazine (155.0 g) is added to a suspension of 6-(5-chloropyrid-
2-yl)-7-oxo-5-phenoxycarbonyloxy-5,6-dihydropyrrolo[3,4-b]pyrazine (194.0
g) in acetone (970 ml) cooled to a temperature of about 3°C. The reaction
mixture is stirred for 3 h at a temperature of about 3°C and is then poured
into water (5000 ml). The product which precipitates is filtered off and then
washed with water (600 ml) and dried. This product is treated with methylene
chloride (1100 ml) at a temperature of about 20°C. The insoluble material is
filtered off and then the filtrate is washed with 1 N sodium hydroxide solution
(3x200 ml) and with water (3x200 ml). The organic phase is treated with
decolorizing charcoal (10.0 g), dried over potassium carbonate, filtered and
then concentrated to dryness under reduced pressure. The oily residue
obtained is dissolved in boiling acetonitrile (500 ml). The 101.0 g of 6-(5-
chloropyrid-2-yl)-5-(4-methylpiperazin-l-yl)carbonyloxy-7-oxo-5,6-
dihydropyrrolo[3,4-b]-pyrazine are obtained, melting point 178°C (washed
with ice cold acetonitrile, 50 ml, and then crystallizes with diisopropyl ether,
50 ml).
Brand name
IMOVANE
Therapeutic Function
Sedative, Hypnotic
World Health Organization (WHO)
Zopiclone was introduced as a sedative in 1985. It remains
registered in several countries and the World Health Organization is not aware of
any other country that has refused registration.
Clinical Use
Hypnotic
Drug interactions
Potentially hazardous interactions with other drugs
Antibacterials: metabolism inhibited by
erythromycin; concentration significantly reduced by
rifampicin.
Antipsychotics: enhanced sedative effects.
Antivirals: concentration possibly increased by
ritonavir.
Metabolism
Zopiclone is extensively metabolised in the liver via the cytochrome P450 isoenzyme CYP3A4 and, to a lesser extent, CYP2C8; the 2 major metabolites, the less active zopiclone N-oxide and the inactive N-desmethylzopiclone, are excreted mainly in the urine. About 50% of a dose is converted by decarboxylation to inactive metabolites, which are partly eliminated via the lungs as carbon dioxide.
Check Digit Verification of cas no
The CAS Registry Mumber 43200-80-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,3,2,0 and 0 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 43200-80:
(7*4)+(6*3)+(5*2)+(4*0)+(3*0)+(2*8)+(1*0)=72
72 % 10 = 2
So 43200-80-2 is a valid CAS Registry Number.
InChI:InChI=1/C17H17ClN6O3/c1-22-6-8-23(9-7-22)17(26)27-16-14-13(19-4-5-20-14)15(25)24(16)12-3-2-11(18)10-21-12/h2-5,10,16H,6-9H2,1H3/p+1/t16-/m0/s1
43200-80-2Relevant articles and documents
Preparation method of zopiclone intermediate
-
, (2020/06/17)
The invention provides a preparation method of zopiclone. According to the method, anhydride is used as a reaction solvent, pyrazine-2,3-dianhydride and 2-amino-5-chloropyridine are synthesized into 6-(5-chloro-2-pyridyl)-5,7-dioxo-6,7-dihydro-5H-pyrrolo(3,4-b)pyrazine in one step, so that the process is simplified, the obtained product is high in yield and purity, production conditions and environment friendliness are achieved, and the method is suitable for industrial production.
A racemization method of zopiclone
-
Paragraph 0042; 0043, (2016/10/07)
The invention relates to a racemization method of eszopiclone. According to the invention, tetramethylguanidine which is cheap and easily available is used as a racemization agent. The method provided by the invention is simple to operate, is safe and stable, has advantages of high yield and good product quality, and is suitable for industrial production.
A NEW METHOD FOR PREPARATION OF ZOPICLONE AND ITS POLYMORPHS
-
Page/Page column 12, (2009/09/04)
A process for the preparation of crystalline Zopiclone comprising i) suspending zopiclone in a mixture of acetonitrile and diisopropyl ether, filtering and drying the resulting solid; ii) dissolving the solid in step i) in N,N-dimethylformamide to get a clear solution; iii) heating and then precipitating solid; iv) filtering and drying the solid to get crystalline zopiclone. Crystalline zopiclone Form C. Crystalline Zopiclone Form D characterized by an X-ray powder diffraction pattern that comprises peaks with 2theta values of at least 14.8, 19.8, 21.3, 27.3 °2θ ± 0.2 °2θ. A process for preparation of crystalline Zopiclone Form D comprising dissolving Zopiclone in N,N-dimethylformamide and filtering; washing clear filtrate with an alkali solution; separating and concentrating the organic layer, adding isopropyl alcohol thereto and concentrating further to get a slurry; filtering the slurry and drying the resultant solid to get crystalline Zopiclone form D. Pharmaceutical composition comprising crystalline forms of Zopiclone.