Chemical Property of Sanguinine
Chemical Property:
- Appearance/Colour:Pale Yellow Powder
- Vapor Pressure:5.91E-09mmHg at 25°C
- Melting Point:227-230°C (dec.)
- Boiling Point:451.9°C at 760 mmHg
- Flash Point:227.1°C
- PSA：52.93000
- Density:1.37g/cm3
- LogP:1.48520
- Storage Temp.:-20°C Freezer
- XLogP3:1.5
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:0
- Exact Mass:273.13649347
- Heavy Atom Count:20
- Complexity:426
- Purity/Quality:
-
99% *data from raw suppliers
O-DesmethylGalanthamine *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CN1CCC23C=CC(CC2OC4=C(C=CC(=C34)C1)O)O
- Isomeric SMILES:CN1CC[C@@]23C=C[C@@H](C[C@@H]2OC4=C(C=CC(=C34)C1)O)O
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Uses
Sanguinine has a more potent acetylcholinesterase inhibitory activity than galanthamine due to an extra hydroxyl group available for potential interaction with acetylcholinesterase. Sanguinine, in turn, is 10-fold more selective than galanthamine for acetylcholinesterase (AChE) vs. butyrylcholinesterase (BuChE). The lack of AChE inhibitory activity of lycoramine and epinorlicoramine could be due to the occurrence of a double bond in ring C, which does not allow these alkaloids to have the same spatial configuration as the active alkaloids of this series.
