Chemical Property of Galantamine hydrobromide
Chemical Property:
- Appearance/Colour:white to offf-white powder
- Vapor Pressure:0mmHg at 25°C
- Melting Point:256 °C
- Refractive Index:-95 ° (C=1.4, H2O)
- Boiling Point:439.3 °C at 760 mmHg
- Flash Point:219.5 °C
- PSA：41.93000
- LogP:2.74630
- Storage Temp.:−20°C
- Solubility.:Sparingly soluble in water, very slightly soluble in anhydrous ethanol. It dissolves in dilute solutions of alkali hydroxides.
- Water Solubility.:Soluble in water or DMSO
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:1
- Exact Mass:367.07831
- Heavy Atom Count:22
- Complexity:440
- Purity/Quality:
-
≥98.0% *data from raw suppliers
Galanthamine hydrobromide *data from reagent suppliers
Safty Information:
- Pictogram(s):
T
- Hazard Codes:T
- Statements:
25
- Safety Statements:
45-36/37/39-22
- MSDS Files:
-
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:CN1CCC23C=CC(CC2OC4=C(C=CC(=C34)C1)OC)O.Br
- Isomeric SMILES:CN1CC[C@@]23C=C[C@@H](C[C@@H]2OC4=C(C=CC(=C34)C1)OC)O.Br
- Recent ClinicalTrials:Functional Brain Imaging of Medication Treatment Response in Mild Alzheimer's Disease Patients
- Recent EU Clinical Trials:Comparison of therapeutic strategies with Cholinesterase Inhibitors: stop or still (SOS) trial
-
Indications
It is suitable for treatment of benign memory disorders, improving the directed memory, associative learning, image memory, nonsense figure recognition and also portraits recalling capability of the patients. It can also alleviate the symptom of dementia patients and also memory impairment caused by organic brain lesions.
-
Drug Interactions
Galantamine hydrobromide can play a potential role on weakening the treatment efficacy of the anti-cholinergic drug.
It has synergistic effect in combination with cholinomimetic effectors and other kinds of cholinesterase inhibitors.
Combined with cimetidine ketoconazole may increase the bioavailability of the product.
Combination with erythromycin can reduce the efficacy of this product.
It has been reported that the combination between galantamine hydrobromide with digoxin can cause atrioventricular block
-
Uses
It can be used for the treatment of neurological diseases and trauma-induced movement disorders, multiple neuritis, and radiculitis.
Cholinesterase inhibitors can reverse the process of scopolamine-induced amnesia. Galantamine hydrobromide (marketed as Reminyl) is one of a group of three drugs for people with Alzheimer's disease called cholinesterase inhibitors. The other two are called donepezil hydrochloride (common brand name Aricept) and rivastigmine (common brand name Exelon). It is a selective acetylcholinesterase inhibitor that for the treatment and prevention of Alzheimer's disease and other diseases resulting from reduced neuronal metabolism.
