Hexadecanoic acid, 1-[[[hydroxy(4-nitrophenoxy)phosphinyl]oxy]methyl]-1,2-ethanediyl ester

Base Information

• Chemical Name: Hexadecanoic acid, 1-[[[hydroxy(4-nitrophenoxy)phosphinyl]oxy]methyl]-1,2-ethanediyl ester
• CAS No.: 189635-42-5
• Molecular Formula: C41H72NO10P
• Molecular Weight: 769.997
• Mol file: 189635-42-5.mol

Synonyms:

Chemical Property of Hexadecanoic acid, 1-[[[hydroxy(4-nitrophenoxy)phosphinyl]oxy]methyl]-1,2-ethanediyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Hexadecanoic acid, 1-[[[hydroxy(4-nitrophenoxy)phosphinyl]oxy]methyl]-1,2-ethanediyl ester

There total 4 articles about Hexadecanoic acid, 1-[[[hydroxy(4-nitrophenoxy)phosphinyl]oxy]methyl]-1,2-ethanediyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Hexadecanoic acid 2-[chloro-(4-nitro-phenoxy)-phosphoryloxy]-1-hexadecanoyloxymethyl-ethyl ester → 1,2-dipalmitoyl-3-glyceryl p-nitrophenyl phosphate (189635-42-5)

Guidance literature:

In pyridine; water; at 25 ℃; for 1h; Yield given;

DOI:10.1021/ja00277a047

Reference yield:

1-dichlorophosphoryloxy-4-nitro-benzene (777-52-6) + rac-1,2-dipalmitoylglycerol (1042289-75-7) → 1,2-dipalmitoyl-3-glyceryl p-nitrophenyl phosphate (189635-42-5)

Guidance literature:

With triethylamine; In dichloromethane; Yield given; a) RT, 2 h, b) 35 deg C, 10 min;

DOI:10.1021/ja972041+

Reference yield:

1-dichlorophosphoryloxy-4-nitro-benzene (777-52-6) → 1,2-dipalmitoyl-3-glyceryl p-nitrophenyl phosphate (189635-42-5)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether; pyridine / 4 h / 25 °C

2: H₂O; pyridine / 1 h / 25 °C

In pyridine; diethyl ether; water;

DOI:10.1021/ja00277a047

upstream raw materials:

1-dichlorophosphoryloxy-4-nitro-benzene

rac-1,2-dipalmitoylglycerol

Downstream raw materials:

4-nitro-phenol

1-hexadecylcarboxylic acid

Refernces

• 1、 Scrimin, Paolo,Tecilla, Paolo,Moss, Robert A.,Bracken, Kathryn. "Control of permeation of lanthanide ions across phosphate- functionalized liposomal membranes". . p. 1179 - 1185. Retrieved 1998.