2-(4-Chlorophenoxy)acetohydrazide

Base Information

• Chemical Name: 2-(4-Chlorophenoxy)acetohydrazide
• CAS No.: 2381-75-1
• Molecular Formula: C8H9ClN2O2
• Molecular Weight: 200.625
• Hs Code.: 2928000090
• European Community (EC) Number: 818-822-0
• DSSTox Substance ID: DTXSID30178524
• Nikkaji Number: J656.119E
• Wikidata: Q83048950
• Mol file: 2381-75-1.mol

Synonyms:2-(4-chlorophenoxy)acetohydrazide;2381-75-1;4-Chlorophenoxy acetohydrazide;Acetic acid, (4-chlorophenoxy)-, hydrazide;Acetic acid,2-(4-chlorophenoxy)-, hydrazide;(4-Chlorophenoxy)acetic acid hydrazide;(4-Chloro-phenoxy)acetic acid hydrazide;Oprea1_120770;SCHEMBL11547674;DTXSID30178524;JS-211C;p-chlorophenoxyacetic acid hydrazide;BBL015533;MFCD00705185;STK048077;AKOS000116138;CS-0204582;FT-0690432;(4-CHLORO-PHENOXY)-ACETICACIDHYDRAZIDE;EN300-03753;E87812;SR-01000414680;J-505943;SR-01000414680-1;Z56862620;F1099-0050

Chemical Property of 2-(4-Chlorophenoxy)acetohydrazide

Chemical Property:

• Vapor Pressure: 2.28E-07mmHg at 25°C
• Melting Point: 165-167 °C
• Refractive Index: 1.568
• Boiling Point: 423.2 °C at 760 mmHg
• PKA: 12.10±0.35(Predicted)
• Flash Point: 209.7 °C
• PSA: 64.35000
• Density: 1.324 g/cm³
• LogP: 1.79990
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 200.0352552
• Heavy Atom Count: 13
• Complexity: 170

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-Chlorophenoxy)acetohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1OCC(=O)NN)Cl

Technology Process of 2-(4-Chlorophenoxy)acetohydrazide

There total 12 articles about 2-(4-Chlorophenoxy)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(4-chloro-phenoxy)-acetic acid methyl ester (4841-22-9) → (4-chlorophenoxy)acetic acid hydrazide (2381-75-1)

Guidance literature:

With hydrazine hydrate; In methanol; for 0.0166667h; microwave irradiation;

DOI:10.1081/SCC-120027275

Reference yield: 95.0%

ethyl p-chlorophenoxyacetate (14426-42-7) → (4-chlorophenoxy)acetic acid hydrazide (2381-75-1)

Guidance literature:

With hydrazine hydrate; In ethanol; for 6h; Reflux;

Reference yield: 92.0%

2-(4-chlorophenoxy)-N-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)acetamide → 2-amino-1H-benzo[de]isoquinoline-1,3(2H)-dione (5690-46-0) + (4-chlorophenoxy)acetic acid hydrazide (2381-75-1)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Reflux;

DOI:10.1002/chem.202102593

upstream raw materials:

ethyl p-chlorophenoxyacetate

(4-chloro-phenoxy)-acetic acid methyl ester

4-Chlorophenoxyacetic acid

4-chloro-phenol

Downstream raw materials:

4-Chlorphenoxy-essigsaeureisopropylidenhydrazid

C₁₆H₁₆ClN₃O₅S

C₁₅H₁₅ClN₂O₄S

1-(p-chlorophenoxyacetyl)-2-phenylsulfonylhydrazine

Refernces

• 1、 D'Souza, Vineetha Telma,Nayak, Janardhana,D'Mello, Desmond Edward,Dayananda. "Synthesis and characterization of biologically important quinoline incorporated triazole derivatives". . . Retrieved 2020/11/04.
• 2、 Manoj Kumar, Mesram,Venkataramana, Parikibanda,Yadagiri Swamy, Parikibanda,Chityala, Yadaiah. "N-Amino-1,8-Naphthalimide is a Regenerated Protecting Group for Selective Synthesis of Mono-N-Substituted Hydrazines and Hydrazides". supporting information. p. 17713 - 17721. Retrieved 2021/11/10.