Pentanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl](phenylmethyl)amino]ethyl]-2-ethyl-5- oxo-, methyl ester, (3R)-

Base Information

Chemical Name:Pentanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl](phenylmethyl)amino]ethyl]-2-ethyl-5- oxo-, methyl ester, (3R)-
CAS No.:189952-74-7
Molecular Formula:C22H33NO5
Molecular Weight:391.508
Hs Code.:

Synonyms:

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Chemical Property of Pentanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl](phenylmethyl)amino]ethyl]-2-ethyl-5- oxo-, methyl ester, (3R)-

Chemical Property:

Purity/Quality:

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Technology Process of Pentanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl](phenylmethyl)amino]ethyl]-2-ethyl-5- oxo-, methyl ester, (3R)-

There total 11 articles about Pentanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl](phenylmethyl)amino]ethyl]-2-ethyl-5- oxo-, methyl ester, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 189952-73-6
(R)-5-(Benzyl-tert-butoxycarbonyl-amino)-3-[1,3]dithian-2-ylmethyl-2-ethyl-pentanoic acid methyl ester

: 189952-74-7
(R)-5-(Benzyl-tert-butoxycarbonyl-amino)-2-ethyl-3-(2-oxo-ethyl)-pentanoic acid methyl ester

Guidance literature:: With mercury(II) perchlorate; calcium carbonate; In tetrahydrofuran;
DOI:10.1039/a700856b

Reference yield:

: 1004-20-2
cis-3-Oxycyclopentyl-essigsaeure-lacton

: 189952-74-7
(R)-5-(Benzyl-tert-butoxycarbonyl-amino)-2-ethyl-3-(2-oxo-ethyl)-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 75 percent / 180 °C

2: LAH / tetrahydrofuran / Heating

3: aq. NaOH / Ambient temperature

4: 95 percent / PCC, NaOAc / CH₂Cl₂ / Ambient temperature

5: 1.) pyrrolidine, 2.) Et₃N / 1.) C₆H₆, reflux, 2.) MeCN

6: KOH / 2-methyl-propan-2-ol / 60 °C

8: 73 percent / NaN(SiMe₃)2 / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C

9: 92 percent / aq. Hg(ClO₄)2, CaCO₃ / tetrahydrofuran

With pyrrolidine; potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; mercury(II) perchlorate; sodium acetate; sodium hexamethyldisilazane; triethylamine; pyridinium chlorochromate; calcium carbonate; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; tert-butyl alcohol;
DOI:10.1039/a700856b

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 189952-74-7
(R)-5-(Benzyl-tert-butoxycarbonyl-amino)-2-ethyl-3-(2-oxo-ethyl)-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: aq. NaOH / Ambient temperature

2: 95 percent / PCC, NaOAc / CH₂Cl₂ / Ambient temperature

3: 1.) pyrrolidine, 2.) Et₃N / 1.) C₆H₆, reflux, 2.) MeCN

4: KOH / 2-methyl-propan-2-ol / 60 °C

6: 73 percent / NaN(SiMe₃)2 / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C

7: 92 percent / aq. Hg(ClO₄)2, CaCO₃ / tetrahydrofuran

With pyrrolidine; potassium hydroxide; sodium hydroxide; mercury(II) perchlorate; sodium acetate; sodium hexamethyldisilazane; triethylamine; pyridinium chlorochromate; calcium carbonate; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; tert-butyl alcohol;
DOI:10.1039/a700856b