(R)-5-(Benzyl-tert-butoxycarbonyl-amino)-3-[1,3]dithian-2-ylmethyl-2-ethyl-pentanoic acid methyl ester

Base Information

Chemical Name:(R)-5-(Benzyl-tert-butoxycarbonyl-amino)-3-[1,3]dithian-2-ylmethyl-2-ethyl-pentanoic acid methyl ester
CAS No.:189952-73-6
Molecular Formula:C₂₅H₃₉NO₄S₂
Molecular Weight:481.721
Hs Code.:

Synonyms:(R)-5-(Benzyl-tert-butoxycarbonyl-amino)-3-[1,3]dithian-2-ylmethyl-2-ethyl-pentanoic acid methyl ester

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Chemical Property of (R)-5-(Benzyl-tert-butoxycarbonyl-amino)-3-[1,3]dithian-2-ylmethyl-2-ethyl-pentanoic acid methyl ester

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Technology Process of (R)-5-(Benzyl-tert-butoxycarbonyl-amino)-3-[1,3]dithian-2-ylmethyl-2-ethyl-pentanoic acid methyl ester

There total 10 articles about (R)-5-(Benzyl-tert-butoxycarbonyl-amino)-3-[1,3]dithian-2-ylmethyl-2-ethyl-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 75-03-6
ethyl iodide

: 189952-72-5
(S)-5-(Benzyl-tert-butoxycarbonyl-amino)-3-[1,3]dithian-2-ylmethyl-pentanoic acid methyl ester

: 189952-73-6
(R)-5-(Benzyl-tert-butoxycarbonyl-amino)-3-[1,3]dithian-2-ylmethyl-2-ethyl-pentanoic acid methyl ester

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -78 ℃;
DOI:10.1039/a700856b

Reference yield:

: 1004-20-2
cis-3-Oxycyclopentyl-essigsaeure-lacton

: 189952-73-6
(R)-5-(Benzyl-tert-butoxycarbonyl-amino)-3-[1,3]dithian-2-ylmethyl-2-ethyl-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 75 percent / 180 °C

2: LAH / tetrahydrofuran / Heating

3: aq. NaOH / Ambient temperature

4: 95 percent / PCC, NaOAc / CH₂Cl₂ / Ambient temperature

5: 1.) pyrrolidine, 2.) Et₃N / 1.) C₆H₆, reflux, 2.) MeCN

6: KOH / 2-methyl-propan-2-ol / 60 °C

8: 73 percent / NaN(SiMe₃)2 / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C

With pyrrolidine; potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; sodium acetate; sodium hexamethyldisilazane; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; tert-butyl alcohol;
DOI:10.1039/a700856b

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 189952-73-6
(R)-5-(Benzyl-tert-butoxycarbonyl-amino)-3-[1,3]dithian-2-ylmethyl-2-ethyl-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: aq. NaOH / Ambient temperature

2: 95 percent / PCC, NaOAc / CH₂Cl₂ / Ambient temperature

3: 1.) pyrrolidine, 2.) Et₃N / 1.) C₆H₆, reflux, 2.) MeCN

4: KOH / 2-methyl-propan-2-ol / 60 °C

6: 73 percent / NaN(SiMe₃)2 / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C

With pyrrolidine; potassium hydroxide; sodium hydroxide; sodium acetate; sodium hexamethyldisilazane; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; tert-butyl alcohol;
DOI:10.1039/a700856b