2-amino-9-[(1S,2R,3S)-2-fluoro-3-(hydroxymethyl)cyclopentyl]-3,9-dihydro-6H-purin-6-one

Base Information

Chemical Name:2-amino-9-[(1S,2R,3S)-2-fluoro-3-(hydroxymethyl)cyclopentyl]-3,9-dihydro-6H-purin-6-one
CAS No.:129746-13-0
Molecular Formula:C₁₁H₁₄FN₅O₂
Molecular Weight:267.263
Hs Code.:

Synonyms:6H-Purin-6-one,2-amino-9-[2-fluoro-3-(hydroxymethyl)cyclopentyl]-1,9-dihydro-, (1a,2a,3a)- (9CI); 6H-Purin-6-one,2-amino-9-[2-fluoro-3-(hydroxymethyl)cyclopentyl]-1,9-dihydro-, (1a,2a,3a)-(?à)-

Suppliers and Price of 2-amino-9-[(1S,2R,3S)-2-fluoro-3-(hydroxymethyl)cyclopentyl]-3,9-dihydro-6H-purin-6-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-amino-9-[(1S,2R,3S)-2-fluoro-3-(hydroxymethyl)cyclopentyl]-3,9-dihydro-6H-purin-6-one

Chemical Property:

Vapor Pressure:3.04E-15mmHg at 25°C
Boiling Point:600°Cat760mmHg
Flash Point:316.6°C
Density:1.86g/cm³

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-amino-9-[(1S,2R,3S)-2-fluoro-3-(hydroxymethyl)cyclopentyl]-3,9-dihydro-6H-purin-6-one

There total 19 articles about 2-amino-9-[(1S,2R,3S)-2-fluoro-3-(hydroxymethyl)cyclopentyl]-3,9-dihydro-6H-purin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 119895-90-8
triphenylmethoxymethylcyclopent-2-ene

: 129746-13-0,129829-89-6
2-Amino-9-((1R,2R,3R)-2-fluoro-3-hydroxymethyl-cyclopentyl)-1,9-dihydro-purin-6-one

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) dimethyldibromohydantoin, 2.) K₂CO₃ / 1.) H₂O, acetone, 0 deg C, 2.) MeOH

2: 84 percent / NaN₃, NH₄Cl / ethanol; H₂O / 90 °C

3: diethylaminosulphur trifluoride (DAST) / CH₂Cl₂ / 0 °C

4: H₂ / Lindlar catalyst / ethanol

5: Et₃N / dimethylformamide / 80 °C

6: AcONa/AcOH, H₂O

7: Zn/AcOH / ethanol; H₂O / 70 °C

8: H⁺ / dimethylformamide

9: HCl / 5 h / Heating

With hydrogenchloride; sodium azide; dimethyldibromohydantoin; diethylamino-sulfur trifluoride; water; hydrogen; sodium acetate; hydrogen cation; potassium carbonate; ammonium chloride; acetic acid; triethylamine; zinc; Lindlar's catalyst; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/c39900000151

Reference yield:

: 119895-90-8
triphenylmethoxymethylcyclopent-2-ene

: 129746-13-0,129829-89-6
2-Amino-9-((1R,2S,3R)-2-fluoro-3-hydroxymethyl-cyclopentyl)-1,9-dihydro-purin-6-one

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) dimethyldibromohydantoin, 2.) K₂CO₃ / 1.) H₂O, acetone, 0 deg C, 2.) MeOH

2: 84 percent / NaN₃, NH₄Cl / ethanol; H₂O / 90 °C

3: pyridine

4: Bu₄NF / tetrahydrofuran

5: 100 percent / H₂ / Lindlar catalyst / ethanol

6: Et₃N / dimethylformamide / 80 °C

7: AcONa/AcOH, H₂O

8: Zn/AcOH / ethanol; H₂O / 70 °C

9: H⁺ / dimethylformamide

10: HCl / 5 h / Heating

With pyridine; hydrogenchloride; sodium azide; dimethyldibromohydantoin; tetrabutyl ammonium fluoride; water; hydrogen; sodium acetate; hydrogen cation; potassium carbonate; ammonium chloride; acetic acid; triethylamine; zinc; Lindlar's catalyst; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1039/c39900000151

Reference yield:

: 119895-91-9,129829-81-8,129829-82-9,137767-65-8,137767-66-9
2-exo-triphenylmethoxymethyl-6-oxabicyclo<3.1.0>hexane

: 129746-13-0,129829-89-6
2-Amino-9-((1R,2R,3R)-2-fluoro-3-hydroxymethyl-cyclopentyl)-1,9-dihydro-purin-6-one

Guidance literature:: Multi-step reaction with 8 steps

1: 84 percent / NaN₃, NH₄Cl / ethanol; H₂O / 90 °C

2: diethylaminosulphur trifluoride (DAST) / CH₂Cl₂ / 0 °C

3: H₂ / Lindlar catalyst / ethanol

4: Et₃N / dimethylformamide / 80 °C

5: AcONa/AcOH, H₂O

6: Zn/AcOH / ethanol; H₂O / 70 °C

7: H⁺ / dimethylformamide

8: HCl / 5 h / Heating

With hydrogenchloride; sodium azide; diethylamino-sulfur trifluoride; water; hydrogen; sodium acetate; hydrogen cation; ammonium chloride; acetic acid; triethylamine; zinc; Lindlar's catalyst; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/c39900000151