2-Pyrrolidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-, methyl ester

Base Information

• Chemical Name: 2-Pyrrolidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-, methyl ester
• CAS No.: 190734-68-0
• Molecular Formula: C13H23NO4
• Molecular Weight: 257.33
• Mol file: 190734-68-0.mol

Synonyms:

Chemical Property of 2-Pyrrolidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-, methyl ester

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Pyrrolidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-, methyl ester

There total 1 articles about 2-Pyrrolidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

tert-butyl pyrrolidine-1-carboxylate (86953-79-9) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl 1-[(1,1-dimethylethoxy)carbonyl]-2-pyrrolidinepropanoate (190734-68-0)

Guidance literature:

tert-butyl pyrrolidine-1-carboxylate; With sec.-butyllithium; (-)-sparteine; In tetrahydrofuran; at -78 ℃; for 1h;

In tetrahydrofuran; at -78 - -55 ℃; for 0.75h;

acrylic acid methyl ester; With chloro-trimethyl-silane; In tetrahydrofuran; at -78 - 20 ℃; for 2h; Further stages.;

DOI:10.1021/jo0056038

Reference yield: 89.0%

methyl 1-[(1,1-dimethylethoxy)carbonyl]-2-pyrrolidinepropanoate (190734-68-0) → 1,2,5,6,7,8-hexahydro-3H-pyrrolizin-3-one (32548-24-6)

Guidance literature:

With chloro-trimethyl-silane; phenol; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/jo016053w

upstream raw materials:

tert-butyl pyrrolidine-1-carboxylate

acrylic acid methyl ester

Downstream raw materials:

1,2,5,6,7,8-hexahydro-3H-pyrrolizin-3-one