Methanesulfonic acid,(1R)-1-methylpropyl ester

Base Information

• Chemical Name: Methanesulfonic acid,(1R)-1-methylpropyl ester
• CAS No.: 66194-68-1
• Molecular Formula: C5H12O3S
• Molecular Weight: 152.214
• Hs Code.: 2905199090
• Mol file: 66194-68-1.mol

Synonyms:(R)-Isobutyl methanesulfonate;(2R)-2-methylsulfonyloxybutane;Methanesulfonic acid, 1-methylpropyl ester, (R)-;(R)-2-Butylmethanesulfonate;

Chemical Property of Methanesulfonic acid,(1R)-1-methylpropyl ester

Chemical Property:

• Vapor Pressure: 0.0714mmHg at 25°C
• Refractive Index: 1.428
• Boiling Point: 236.8°C at 760 mmHg
• Flash Point: 97°C
• PSA: 51.75000
• Density: 1.096g/cm³
• LogP: 1.84190

Purity/Quality:

Methanesulfonic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methanesulfonic acid,(1R)-1-methylpropyl ester

There total 2 articles about Methanesulfonic acid,(1R)-1-methylpropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

(2R)-butan-2-ol (14898-79-4) + methanesulfonyl chloride (124-63-0) → S-(+)-methanesulfonic acid sec-butyl ester (66194-68-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

(2R)-butan-2-ol (14898-79-4) → S-(+)-methanesulfonic acid sec-butyl ester (66194-68-1)

Guidance literature:

With diethyl ether; sodium hydride; anschliessend mit Methansulfonylchlorid;

DOI:10.1021/jo01356a001

Reference yield:

S-(+)-methanesulfonic acid sec-butyl ester (66194-68-1) → 2-butyl iodide (513-48-4,52152-71-3)

Guidance literature:

With sodium iodide; In acetone; at 51 ℃; for 19h;

DOI:10.1016/j.tetlet.2010.03.041

upstream raw materials:

(2R)-butan-2-ol

methanesulfonyl chloride

Downstream raw materials:

C₁₄H₁₇F₃O₂S

2-butyl iodide

diethyl (1-methylpropyl)phosphonate

(S)-(+)-2-butyl p-tolyl sulfide

Refernces

• 1、 -. "COMPOUNDS AND COMPOSITIONS FOR TREATING CNS DISORDERS". Paragraph 0165; 0199. . Retrieved 2021/07/10.
• 2、 Ralph, Glenn,Biscoe, Mark R.. "Preparation of Enantioenriched Alkylcarbastannatranes via Nucleophilic Inversion of Alkyl Mesylates for Use in Stereospecific Cross-Coupling Reactions". supporting information. p. 3912 - 3915. Retrieved 2019/10/02.