2-Anilino-4-methoxybenzoic acid

Base Information

• Chemical Name: 2-Anilino-4-methoxybenzoic acid
• CAS No.: 19218-83-8
• Molecular Formula: C14H13NO3
• Molecular Weight: 243.262
• ChEMBL ID: CHEMBL2043311
• DSSTox Substance ID: DTXSID10505617
• Wikidata: Q82360851
• Mol file: 19218-83-8.mol

Synonyms:2-anilino-4-methoxybenzoic acid;CHEMBL2043311;19218-83-8;4-methoxy-2-(phenylamino)benzoic acid;2-anilino4methoxybenzoic acid;SCHEMBL293867;DTXSID10505617;MFKNPBLMWQGRDT-UHFFFAOYSA-N;BDBM50385723;FT-0757869

Chemical Property of 2-Anilino-4-methoxybenzoic acid

Chemical Property:

• XLogP3: 4.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 243.08954328
• Heavy Atom Count: 18
• Complexity: 276

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)C(=O)O)NC2=CC=CC=C2

Technology Process of 2-Anilino-4-methoxybenzoic acid

There total 10 articles about 2-Anilino-4-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-methoxy-2-(phenylamino)benzoic acid methyl ester (21971-23-3) → 5-methoxydiphenylamine-2-carboxylic acid (19218-83-8)

Guidance literature:

With sodium hydroxide; water; In tetrahydrofuran; methanol; at 60 ℃; for 4h; Product distribution / selectivity;

Reference yield: 40.0%

2-chloro-4-methoxybenzoic acid (21971-21-1) + aniline (62-53-3) → 5-methoxydiphenylamine-2-carboxylic acid (19218-83-8)

Guidance literature:

With copper;

DOI:10.1021/jo00324a025

Reference yield:

aniline (62-53-3) → 5-methoxydiphenylamine-2-carboxylic acid (19218-83-8) + 3-methoxy-N-phenylaniline (101-16-6)

Guidance literature:

With i-Amyl alcohol; copper;

upstream raw materials:

2-chloro-4-methoxybenzoic acid

aniline

iodobenzene

4-methoxyanthranilic acid

Downstream raw materials:

3-methoxyacridine-9(10H)-one

2-anilino-N-cyclopropyl-4-methoxybenzamide

2-anilino-4-methoxy-N-methylbenzamide