Decanoic acid, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-hydroxy-4,4,6-trimethyl-3-oxo- 10-(phenylmethoxy)-, 1,1-dimethylethyl ester, (5S,6S,7S)-

Base Information

Chemical Name:Decanoic acid, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-hydroxy-4,4,6-trimethyl-3-oxo- 10-(phenylmethoxy)-, 1,1-dimethylethyl ester, (5S,6S,7S)-
CAS No.:192370-74-4
Molecular Formula:C30H52O6Si
Molecular Weight:536.825
Hs Code.:

Decanoic acid,
7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-hydroxy-4,4,6-trimethyl-3-oxo-
10-(phenylmethoxy)-, 1,1-dimethylethyl ester, (5S,6S,7S)-

Synonyms:

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Chemical Property of Decanoic acid, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-hydroxy-4,4,6-trimethyl-3-oxo- 10-(phenylmethoxy)-, 1,1-dimethylethyl ester, (5S,6S,7S)-

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Technology Process of Decanoic acid, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-hydroxy-4,4,6-trimethyl-3-oxo- 10-(phenylmethoxy)-, 1,1-dimethylethyl ester, (5S,6S,7S)-

There total 6 articles about Decanoic acid, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-hydroxy-4,4,6-trimethyl-3-oxo- 10-(phenylmethoxy)-, 1,1-dimethylethyl ester, (5S,6S,7S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 94250-54-1
tert-butyl 4-methyl-3-oxopentanoate

: 192370-73-3
(2R,3S)-6-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-2-methylhexanal

: 192370-74-4
(5S,6S,7S)-10-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-4,4,6-trimethyl-3-oxo-decanoic acid tert-butyl ester

Guidance literature:: With n-butyllithium; sodium hydride; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 1h;

Reference yield:

: 5470-84-8
4-benzyloxybutanal

: 192370-74-4
(5S,6S,7S)-10-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-4,4,6-trimethyl-3-oxo-decanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 2.) aq. NaOH, H₂O₂ / 1.) Et₂O, -78 deg C

2: 2,6-lutidine / CH₂Cl₂

3: 82 percent / O₃; DMS / CH₂Cl₂; methanol / -78 °C

4: NaH, BuLi / 0 °C

With 2,6-dimethylpyridine; sodium hydroxide; n-butyllithium; 2,3-dimercapto-succinic acid; dihydrogen peroxide; sodium hydride; ozone; In methanol; dichloromethane;
DOI:10.1016/S0040-4039(97)00931-3

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 192370-74-4
(5S,6S,7S)-10-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-4,4,6-trimethyl-3-oxo-decanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 2,6-lutidine / CH₂Cl₂

2: 82 percent / O₃; DMS / CH₂Cl₂; methanol / -78 °C

3: NaH, BuLi / 0 °C

With 2,6-dimethylpyridine; n-butyllithium; 2,3-dimercapto-succinic acid; sodium hydride; ozone; In methanol; dichloromethane;
DOI:10.1016/S0040-4039(97)00931-3