192370-73-3

Upstream product

• 109307-91-7 2-methyl-6-(phenylmethoxy)-2(E)-hexen-1-ol 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 109307-90-6 ethyl 2-methyl-6-(phenylmethoxy)-2(E)-hexenoate 
• 4541-14-4 4-benzyloxy-butan-1-ol 
• 100-39-0 benzyl bromide 
• 1262206-04-1 (2R,3S)-1-((S)-4-benzyl-2-thioxothiazolidin-3-yl)-6-(benzyloxy)-3-(terttertbutyldimethylsilyloxy)-2-methylhexan-1-one 
• 1262206-03-0 (2R,3S)-1-((S)-4-benzyl-2-thioxothiazolidin-3-yl)-6-(benzyloxy)-3-hydroxy-2-methylhexan-1-one 
• 219824-47-2 (3S,4S)-7-(benzyloxy)-3-methylhept-1-en-4-ol 
• 5470-84-8 4-benzyloxybutanal 
• 192370-72-2 [(1S,2S)-1-(3-Benzyloxy-propyl)-2-methyl-but-3-enyloxy]-tert-butyl-dimethyl-silane 

Downstream Products

• 192370-74-4 (5S,6S,7S)-10-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-4,4,6-trimethyl-3-oxo-decanoic acid tert-butyl ester 
• 1262206-05-2 (4S,5S,E)-ethyl 8-(benzyloxy)-5-(tert-butyldimethylsilyloxy)-4-methyloct-2-enoate 
• 1185202-64-5 ethyl 2-((2R,3S,5S,6S)-6-(3-(benzyloxy)propyl)-3-hydroxy-5-methyltetrahydro-2H-pyran-2-yl)acetate 
• 1262206-07-4 (4S,5S)-8-(benzyloxy)-5-(tert-butyldimethylsilyloxy)-4-methyloctanal 
• 1262206-08-5 (4S,6S,7S,E)-ethy 10-(benzyloxy)-7-(tert-butyldimethylsilyloxy)-4-hydroxy-6-methyldec-2-enoate 
• 1262206-06-3 (4S,5S,E)-8-(benzyloxy)-5-(tert-butyldimethylsilyloxy)-4-methyloct-2-en-1-ol 
• 192370-83-5 (3S,6R,7S)-10-Benzyloxy-3,7-bis-(tert-butyl-dimethyl-silanyloxy)-4,4,6-trimethyl-5-oxo-decanoic acid tert-butyl ester 
• 192370-75-5 (3S,5S,6S,7S)-10-Benzyloxy-3,7-bis-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-4,4,6-trimethyl-decanoic acid tert-butyl ester 

Relevant academic research and scientific papers

A formal stereoselective synthesis of (-)-brevisamide

An efficient stereoselective formal synthesis of marine derived monocyclic ether (-)-brevisamide is reported. The key steps involved in this synthesis are syn-Aldol reaction, Sharpless asymmetric epoxidation, and stereoselective construction of tetrahydropyran ring by 6-endo-cyclization of suitably substituted hydroxy styrylepoxide.

Palladium hydroxide catalyzed isomerization of primary allylic alcohols to aldehydes: Application to the formal synthesis of (-)-brevisamide

The Pd-catalyzed isomerization of primary allylic alcohols into the corresponding saturated aldehydes has been achieved at room temperature for the first time in good to excellent yields under mild conditions. The functional group compatibility in this reaction is studied, and this new methodology has been successfully applied in the synthesis of a C5-C13 tetrahydropyran ring system of (-)-brevisamide in seven steps.

Synthesis of epothilones, intermediates thereto, analogues and uses thereof

The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.

Stereoselective syntheses and evaluation of compounds in the 8-desmethylepothilone a series: Some surprising observations regarding their chemical and biological properties

The title compounds have been synthesized in a convergent way by recourse to a Weiler type dianion construction.