Technology Process of 8-Azabicyclo[3.2.1]octane-2-carboxylic acid,
3-(3,4-dichlorophenyl)-8-methyl-, methyl ester, (1R,2S,3R,5S)-
There total 8 articles about 8-Azabicyclo[3.2.1]octane-2-carboxylic acid,
3-(3,4-dichlorophenyl)-8-methyl-, methyl ester, (1R,2S,3R,5S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
O-1109;
With
samarium diiodide;
In
tetrahydrofuran;
at -78 ℃;
for 0.75h;
Inert atmosphere;
With
methanol;
In
tetrahydrofuran;
at -78 ℃;
for 3h;
With
water; trifluoroacetic acid;
In
tetrahydrofuran;
at -78 - 20 ℃;
DOI:10.1021/jacs.0c00861
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium bistrimethylsilylamide / tetrahydrofuran / 0.5 h / -78 °C
1.2: 97 percent / tetrahydrofuran / -78 - 22 °C
2.1: 83 percent / LiCl; aq. Na2CO3; Pd2dba3 / various solvent(s) / 3 h / Heating
3.1: SmI2 / tetrahydrofuran / 0.75 h / -78 °C
3.2: 29 percent / MeOH / tetrahydrofuran / 2 h
With
tris-(dibenzylideneacetone)dipalladium(0); samarium diiodide; sodium hexamethyldisilazane; sodium carbonate; lithium chloride;
In
tetrahydrofuran;
2.1: Suzuki coupling;
DOI:10.1021/jm0301484
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 83 percent / LiCl; aq. Na2CO3; Pd2dba3 / various solvent(s) / 3 h / Heating
2.1: SmI2 / tetrahydrofuran / 0.75 h / -78 °C
2.2: 29 percent / MeOH / tetrahydrofuran / 2 h
With
tris-(dibenzylideneacetone)dipalladium(0); samarium diiodide; sodium carbonate; lithium chloride;
In
tetrahydrofuran;
1.1: Suzuki coupling;
DOI:10.1021/jm0301484
