3,4-Difluorothiophene

Base Information

• Chemical Name: 3,4-Difluorothiophene
• CAS No.: 19259-15-5
• Molecular Formula: C4H2F2S
• Molecular Weight: 120.12000
• Mol file: 19259-15-5.mol

Synonyms:

Chemical Property of 3,4-Difluorothiophene

Chemical Property:

• Boiling Point: 99.3±20.0 °C(Predicted)
• PSA: 28.24000
• Density: 1.375±0.06 g/cm3(Predicted)
• LogP: 2.02630

Purity/Quality:

≥99.0% ^*data from raw suppliers

3,4-difluorothiophene 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-Difluorothiophene

There total 2 articles about 3,4-Difluorothiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.7%

3,3,4,4-tetrafluorotetrahydrothiophene (1507363-74-7) → 3,4-difluorothiophene (19259-15-5)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 16h;

Reference yield:

2,2,3,3-tetrafluorobutane-1,4-diyl bis(4-methylbenzenesulfonate) (122834-95-1) → 3,3,4,4-tetrafluorooxolane (374-33-4) + 3,4-difluorothiophene (19259-15-5)

Guidance literature:

2,2,3,3-tetrafluorobutane-1,4-diyl bis(4-methylbenzenesulfonate); With sodium sulfide hydrate; In N,N-dimethyl acetamide; at 70 ℃; for 8h; Inert atmosphere;

With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 1h; Reagent/catalyst;

DOI:10.1021/jo402373x

upstream raw materials:

2,2,3,3-tetrafluorobutane-1,4-diyl bis(4-methylbenzenesulfonate)

3,3,4,4-tetrafluorotetrahydrothiophene