3,3,4,4-Tetrafluorooxolane

Base Information

• Chemical Name: 3,3,4,4-Tetrafluorooxolane
• CAS No.: 374-33-4
• Molecular Formula: C₄H₄F₄O
• Molecular Weight: 144.069
• Hs Code.: 2932190090
• DSSTox Substance ID: DTXSID10382081
• Nikkaji Number: J940.938F
• Wikidata: Q82173383
• Mol file: 374-33-4.mol

Synonyms:3,3,4,4-tetrafluorooxolane;374-33-4;3,3,4,4-Tetrafluorotetrahydrofuran;SCHEMBL3942071;3,3,4,4-Tetrafluorohydrofuran;DTXSID10382081;HCVCNRFVUUDZOP-UHFFFAOYSA-N;MFCD02093328;3,3,4,4-tetrakis(fluoranyl)oxolane;AKOS006228204;3,3,4,4-Tetrafluoro-1-oxacyclopentane;FT-0676254;3-(N,N-DIMETHOXYCARBONYL)AMINOACETANILIDE;A823648

Chemical Property of 3,3,4,4-Tetrafluorooxolane

Chemical Property:

• Vapor Pressure: 335mmHg at 25°C
• Refractive Index: 1.32
• Boiling Point: 82
• PSA: 9.23000
• Density: 1.38g/cm³
• LogP: 1.28720
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 144.01982740
• Heavy Atom Count: 9
• Complexity: 108

Purity/Quality:

97% ^*data from raw suppliers

3,3,4,4-Tetrafluorotetrahydrofuran ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(C(CO1)(F)F)(F)F

Technology Process of 3,3,4,4-Tetrafluorooxolane

There total 5 articles about 3,3,4,4-Tetrafluorooxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2,3,3-tetrafluorobutane-1,4-diyl bis(4-methylbenzenesulfonate) (122834-95-1) → 3,3,4,4-tetrafluorooxolane (374-33-4) + 3,4-difluorothiophene (19259-15-5)

Guidance literature:

2,2,3,3-tetrafluorobutane-1,4-diyl bis(4-methylbenzenesulfonate); With sodium sulfide hydrate; In N,N-dimethyl acetamide; at 70 ℃; for 8h; Inert atmosphere;

With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 1h; Reagent/catalyst;

DOI:10.1021/jo402373x

Reference yield:

2,2,3,3-tetrafluorobutane-1,4-diyl bis(4-methylbenzenesulfonate) (122834-95-1) → 3,3,4,4-tetrafluorooxolane (374-33-4) + 2,3,4-trifluorothiophene (396100-64-4)

Guidance literature:

2,2,3,3-tetrafluorobutane-1,4-diyl bis(4-methylbenzenesulfonate); With sodium sulfide hydrate; In N,N-dimethyl acetamide; at 70 ℃; for 8h; Inert atmosphere;

With Selectfluor; In sulfolane; at 60 ℃; for 2.5h;

With potassium hydroxide; In dimethyl sulfoxide; for 0.75h; Reagent/catalyst; Heating;

DOI:10.1021/jo402373x

Reference yield:

2,2,3,3-tetrafluorobutane-1,4-diol (425-61-6) → 3,3,4,4-tetrafluorooxolane (374-33-4)

Guidance literature:

With sulfuric acid; at 185 ℃;

DOI:10.1021/ja01141a059

upstream raw materials:

2,2,3,3-tetrafluorobutane-1,4-diol

2,2,3,3-tetrafluorobutane-1,4-diyl bis(4-methylbenzenesulfonate)

Downstream raw materials:

2,3,3,4,4-Pentafluoro-tetrahydro-furan

(2R,5S)-2,3,3,4,4,5-Hexafluoro-tetrahydro-furan