Benzoxazole,4-Methoxy-

Base Information

• Chemical Name: Benzoxazole,4-Methoxy-
• CAS No.: 192753-32-5
• Molecular Formula: C8H7NO2
• Molecular Weight: 0.00000
• Mol file: 192753-32-5.mol

Synonyms:

Chemical Property of Benzoxazole,4-Methoxy-

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-Methoxybenzo[d]oxazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoxazole,4-Methoxy-

There total 4 articles about Benzoxazole,4-Methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

4-Hydroxybenzoxazole (89590-22-7) + methyl iodide (74-88-4) → 4-Methoxybenzoxazole (192753-32-5)

Guidance literature:

With potassium carbonate; In acetonitrile; at 80 ℃; for 16h;

Reference yield:

4-Hydroxybenzoxazole (89590-22-7) + potassium carbonate (584-08-7) + methyl iodide (74-88-4) → 4-Methoxybenzoxazole (192753-32-5)

Guidance literature:

In acetone;

Reference yield:

2-nitroresorcinol (601-89-8) → 4-Methoxybenzoxazole (192753-32-5)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium on activated charcoal; hydrogen / ethanol / 4 h / 0 - 20 °C / Inert atmosphere

2: toluene-4-sulfonic acid / 0.5 h / Inert atmosphere; Reflux

3: potassium carbonate / acetone / 2 h / 80 °C

With palladium on activated charcoal; hydrogen; potassium carbonate; toluene-4-sulfonic acid; In ethanol; acetone;

upstream raw materials:

4-Hydroxybenzoxazole

methyl iodide

potassium carbonate

2-nitroresorcinol

Refernces

• 1、 -. "COMPOUND HAVING ZNF143 INHIBITORY ACTIVITY AND USE THEREOF". Paragraph 0089; 0091. . Retrieved 2016/10/27.
• 2、 -. "Bicyclic aryl carboxamides and their therapeutic use". Page column 14. . Retrieved 2010/02/05.