Technology Process of 6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid,
9-(benzoylamino)octahydro-6,10-dioxo-, 1,1-dimethylethyl ester,
(1S,9S)-
There total 15 articles about 6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid,
9-(benzoylamino)octahydro-6,10-dioxo-, 1,1-dimethylethyl ester,
(1S,9S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 12 steps
1: 1.) nBuLi / 1.) THF, -78 deg C, 2.) THF
2: 1.) LDA, 2.) Bu4NI, DMPU / 1.) THF, -78 deg C, 2.) CH2Cl2
3: 98 percent / LiOH / tetrahydrofuran; H2O
4: 100 percent / CH2Cl2
5: 98 percent / aq. NaOH / toluene
6: 85 percent / H2SO4 / dioxane
7: aq. NaHCO3
8: 97 percent / H2 / Pd/C / methanol
9: PCl5 / tetrahydrofuran
10: N-ethylmorpholine / tetrahydrofuran
11: 98 percent / NH2MH2*H2O / ethanol
12: 97 percent / aq. NaHCO3
With
N-ethylmorpholine;; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium hydroxide; sodium hydroxide; n-butyllithium; phosphorus pentachloride; sulfuric acid; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; hydrazine; lithium diisopropyl amide;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; toluene;
DOI:10.1016/S0960-894X(99)00236-X
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 98 percent / TEA / tetrahydrofuran / Heating
2: PCl5 / CH2Cl2
3: aq. NaHCO3
4: 97 percent / H2 / Pd/C / methanol
5: PCl5 / tetrahydrofuran
6: N-ethylmorpholine / tetrahydrofuran
7: 98 percent / NH2MH2*H2O / ethanol
8: 97 percent / aq. NaHCO3
With
N-ethylmorpholine;; TEA; phosphorus pentachloride; hydrogen; sodium hydrogencarbonate; hydrazine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1016/S0960-894X(99)00236-X
