3-Phenyltetrahydropyrrolo[2,1-b][1,3]oxazol-5(6H)-one

Base Information

Chemical Name:3-Phenyltetrahydropyrrolo[2,1-b][1,3]oxazol-5(6H)-one
CAS No.:122383-34-0
Molecular Formula:C12H13 N O2
Molecular Weight:203.24
Hs Code.:
DSSTox Substance ID:DTXSID30924149
Wikidata:Q82898288
Mol file:122383-34-0.mol

Synonyms:DTXSID30924149;3-Phenyltetrahydropyrrolo[2,1-b][1,3]oxazol-5(6H)-one

Suppliers and Price of 3-Phenyltetrahydropyrrolo[2,1-b][1,3]oxazol-5(6H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(3S,CIS)-(-)-3-PHENYLTETRAHYDROPYRROLO-[2,1-B]-OXAZOL-5(6H)-ONE 95.00%
5MG
$ 498.89

Total 7 raw suppliers

Chemical Property of 3-Phenyltetrahydropyrrolo[2,1-b][1,3]oxazol-5(6H)-one

Chemical Property:

Vapor Pressure:4.47E-06mmHg at 25°C
Melting Point:76-80 °C
Refractive Index:1.5260 (estimate)
Boiling Point:383.2°Cat760mmHg
Flash Point:185.6°C
PSA：29.54000
Density:1.25g/cm³
LogP:1.64430
XLogP3:1.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:203.094628657
Heavy Atom Count:15
Complexity:260

Purity/Quality:

99% ^*data from raw suppliers

(3S,CIS)-(-)-3-PHENYLTETRAHYDROPYRROLO-[2,1-B]-OXAZOL-5(6H)-ONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 20/21/22
Safety Statements: 36/37

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(=O)N2C1OCC2C3=CC=CC=C3
Isomeric SMILES:C1CC(=O)N2[C@H]1OC[C@@H]2C3=CC=CC=C3

Technology Process of 3-Phenyltetrahydropyrrolo[2,1-b][1,3]oxazol-5(6H)-one

There total 9 articles about 3-Phenyltetrahydropyrrolo[2,1-b][1,3]oxazol-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 122383-40-8,122383-44-2
5-Ethoxy-1-((S)-2-hydroxy-1-phenyl-ethyl)-pyrrolidin-2-one

: 122383-34-0
(3S,7aR)-5-oxo-3-phenyl-2,3,5,6,7,7a-hexahydropyrrolo<2,1-b>oxazole

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 1h;
DOI:10.1021/jo00278a053

Reference yield: 72.0%

: 1311275-81-6
(S)-N-allyl-N-(2-hydroxy-1-phenylethyl)acrylamide

: 122383-34-0
(3S,7aR)-5-oxo-3-phenyl-2,3,5,6,7,7a-hexahydropyrrolo<2,1-b>oxazole

Guidance literature:: With Hoveyda-Grubbs catalyst first generation; In m-xylene; for 18h; Inert atmosphere; Reflux;
DOI:10.1002/anie.201100417

Reference yield:

: 56613-80-0
D-2-phenylglycinol

: 122383-34-0
(3S,7aR)-5-oxo-3-phenyl-2,3,5,6,7,7a-hexahydropyrrolo<2,1-b>oxazole

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) triethylamine / 1.) toluene, reflux, 1 h, 2.) reflux, 17 h

2: NaBH₄, 2 M HCl / 3 h / Ambient temperature; pH 1-3

With hydrogenchloride; sodium tetrahydroborate; triethylamine;
DOI:10.1021/jo00278a053