(3Z,8α,9R)-3,10-Didehydro-10,11-dihydrocinchonan-6',9-diol

Base Information

• Chemical Name: (3Z,8α,9R)-3,10-Didehydro-10,11-dihydrocinchonan-6',9-diol
• CAS No.: 5985-94-4
• Molecular Formula: C19H22N2O2
• Molecular Weight: 310.3902
• Mol file: 5985-94-4.mol

Synonyms:4-{(R)-[(1S,2S,4S)-5-Eth-(Z)-ylidene-1-aza-bicyclo[2.2.2]oct-2-yl]-hydroxy-methyl}-quinolin-6-ol;(3Z,8S,9R)-10,11-Dihydro-cinchon-3(10)-en-9,6'-diol,Apocuprein;Apocuprein;

Chemical Property of (3Z,8α,9R)-3,10-Didehydro-10,11-dihydrocinchonan-6',9-diol

Chemical Property:

• Boiling Point: 529.6°Cat760mmHg
• Flash Point: 274.1°C
• PSA: 56.59000
• Density: 1.3g/cm³
• LogP: 2.95220

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3Z,8α,9R)-3,10-Didehydro-10,11-dihydrocinchonan-6',9-diol

There total 7 articles about (3Z,8α,9R)-3,10-Didehydro-10,11-dihydrocinchonan-6',9-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Quinine (130-95-0) → apocupreine (5985-94-4)

Guidance literature:

With hydrogenchloride; at 140 - 145 ℃;

Reference yield:

Quinine (130-95-0) → apocupreine (5985-94-4)

Guidance literature:

With sulfuric acid;

DOI:10.1039/jr9340001923 DOI:10.1021/ja01257a045

Reference yield:

Quinine (130-95-0) → apocupreine (5985-94-4) + isoapocupreine (6787-39-9)

Guidance literature:

With sulfuric acid;

DOI:10.1039/jr9340001923 DOI:10.1021/ja01257a045

upstream raw materials:

quinidine

Quinine

(R)-4-((1S,2S,4S,5Z/E)-5-ethylidene-1-azabicyclo[2.2.2]octan-2-yl)hydroxymethyl-6-methoxyquinoline