isoapocupreine

Base Information

• Chemical Name: isoapocupreine
• CAS No.: 6787-39-9
• Molecular Formula: C₁₉H₂₂N₂O₂
• Molecular Weight: 310.396
• Mol file: 6787-39-9.mol

Synonyms:

Chemical Property of isoapocupreine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of isoapocupreine

There total 4 articles about isoapocupreine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Quinine (130-95-0) → apocupreine (5985-94-4) + isoapocupreine (6787-39-9)

Guidance literature:

With sulfuric acid;

DOI:10.1039/jr9340001923 DOI:10.1021/ja01257a045

Reference yield:

(R)-4-((1S,2S,4S,5Z/E)-5-ethylidene-1-azabicyclo[2.2.2]octan-2-yl)hydroxymethyl-6-methoxyquinoline (697260-51-8) → apocupreine (5985-94-4) + isoapocupreine (6787-39-9)

Guidance literature:

With sodium hydride; ethanethiol; In N,N-dimethyl-formamide; mineral oil; at 100 ℃; for 13h; Overall yield = 87 %; Overall yield = 168 mg;

DOI:10.1021/acs.jmedchem.8b01353

Reference yield:

quinidine (56-54-2) → allocupreidine (5985-94-4,6787-39-9,6846-29-3)

Guidance literature:

With sulfuric acid; neoapoquinidine;

upstream raw materials:

quinidine

Quinine

(R)-4-((1S,2S,4S,5Z/E)-5-ethylidene-1-azabicyclo[2.2.2]octan-2-yl)hydroxymethyl-6-methoxyquinoline