1,4-Dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone, 10-[(3-chloro-4-methoxyphenyl)methyl]-7-methyl-3-(2-methylpropyl)-16-[( 1S)-1-[(2R,3R)-3-phenyloxiranyl]ethyl]-, (3S,7R,10R,13E,16S)-

Base Information

Chemical Name:1,4-Dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone, 10-[(3-chloro-4-methoxyphenyl)methyl]-7-methyl-3-(2-methylpropyl)-16-[( 1S)-1-[(2R,3R)-3-phenyloxiranyl]ethyl]-, (3S,7R,10R,13E,16S)-
CAS No.:193070-92-7
Molecular Formula:C₃₅H₄₃ClN₂O₈
Molecular Weight:655.188
Hs Code.:
Mol file:193070-92-7.mol

1,4-Dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone,
10-[(3-chloro-4-methoxyphenyl)methyl]-7-methyl-3-(2-methylpropyl)-16-[(
1S)-1-[(2R,3R)-3-phenyloxiranyl]ethyl]-, (3S,7R,10R,13E,16S)-

Synonyms:

Suppliers and Price of 1,4-Dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone, 10-[(3-chloro-4-methoxyphenyl)methyl]-7-methyl-3-(2-methylpropyl)-16-[( 1S)-1-[(2R,3R)-3-phenyloxiranyl]ethyl]-, (3S,7R,10R,13E,16S)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,4-Dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone, 10-[(3-chloro-4-methoxyphenyl)methyl]-7-methyl-3-(2-methylpropyl)-16-[( 1S)-1-[(2R,3R)-3-phenyloxiranyl]ethyl]-, (3S,7R,10R,13E,16S)-

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Technology Process of 1,4-Dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone, 10-[(3-chloro-4-methoxyphenyl)methyl]-7-methyl-3-(2-methylpropyl)-16-[( 1S)-1-[(2R,3R)-3-phenyloxiranyl]ethyl]-, (3S,7R,10R,13E,16S)-

There total 7 articles about 1,4-Dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone, 10-[(3-chloro-4-methoxyphenyl)methyl]-7-methyl-3-(2-methylpropyl)-16-[( 1S)-1-[(2R,3R)-3-phenyloxiranyl]ethyl]-, (3S,7R,10R,13E,16S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 193070-91-6
(E)-(3S,7R,10R,16S)-10-(3-Chloro-4-methoxy-benzyl)-3-isobutyl-7-methyl-16-((E)-(R)-1-methyl-3-phenyl-allyl)-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone

: 193070-92-7
(E)-(3S,7R,10R,16S)-10-(3-Chloro-4-methoxy-benzyl)-3-isobutyl-7-methyl-16-[(S)-1-((2R,3R)-3-phenyl-oxiranyl)-ethyl]-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone

: (E)-(3S,7R,10R,16S)-10-(3-Chloro-4-methoxy-benzyl)-3-isobutyl-7-methyl-16-[(S)-1-((2S,3S)-3-phenyl-oxiranyl)-ethyl]-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1016/S0960-894X(98)00682-9

Reference yield:

: 162465-33-0
allyl (2S)-2-Hydroxy-4-methylpentanoate

: 193070-92-7
(E)-(3S,7R,10R,16S)-10-(3-Chloro-4-methoxy-benzyl)-3-isobutyl-7-methyl-16-[(S)-1-((2R,3R)-3-phenyl-oxiranyl)-ethyl]-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone

Guidance literature:: Multi-step reaction with 7 steps

1: DCC, DMAP / CH₂Cl₂ / 0 - 25 °C

2: Pd(PPh₃)4, N-methylmorpholine / tetrahydrofuran / 25 °C

3: 95 percent / DCC, DMAP / CH₂Cl₂ / 0 - 25 °C

4: Zn, AcOH

5: TFA / 25 °C

6: 87 percent / FDPP, DIEA / dimethylformamide / 25 °C

7: MCPBA / CH₂Cl₂

With 4-methyl-morpholine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; pentafluorophenyl diphenyl-phosphinate; acetic acid; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; zinc; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(98)00682-9

Reference yield:

: 193071-07-7
(S)-2-((R)-3-tert-Butoxycarbonylamino-butyryloxy)-4-methyl-pentanoic acid

: 193070-92-7
(E)-(3S,7R,10R,16S)-10-(3-Chloro-4-methoxy-benzyl)-3-isobutyl-7-methyl-16-[(S)-1-((2R,3R)-3-phenyl-oxiranyl)-ethyl]-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / DCC, DMAP / CH₂Cl₂ / 0 - 25 °C

2: Zn, AcOH

3: TFA / 25 °C

4: 87 percent / FDPP, DIEA / dimethylformamide / 25 °C

5: MCPBA / CH₂Cl₂

With dmap; pentafluorophenyl diphenyl-phosphinate; acetic acid; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; zinc; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(98)00682-9