1,4-Dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone, 10-[(3-chloro-4-methoxyphenyl)methyl]-7-methyl-16-[(1R,2E)-1-methyl-3 -phenyl-2-propenyl]-3-(2-methylpropyl)-, (3S,7R,10R,13E,16S)-

Base Information

Chemical Name:1,4-Dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone, 10-[(3-chloro-4-methoxyphenyl)methyl]-7-methyl-16-[(1R,2E)-1-methyl-3 -phenyl-2-propenyl]-3-(2-methylpropyl)-, (3S,7R,10R,13E,16S)-
CAS No.:193070-91-6
Molecular Formula:C35H43ClN2O7
Molecular Weight:639.189
Hs Code.:

1,4-Dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone,
10-[(3-chloro-4-methoxyphenyl)methyl]-7-methyl-16-[(1R,2E)-1-methyl-3
-phenyl-2-propenyl]-3-(2-methylpropyl)-, (3S,7R,10R,13E,16S)-

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Chemical Property of 1,4-Dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone, 10-[(3-chloro-4-methoxyphenyl)methyl]-7-methyl-16-[(1R,2E)-1-methyl-3 -phenyl-2-propenyl]-3-(2-methylpropyl)-, (3S,7R,10R,13E,16S)-

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Technology Process of 1,4-Dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone, 10-[(3-chloro-4-methoxyphenyl)methyl]-7-methyl-16-[(1R,2E)-1-methyl-3 -phenyl-2-propenyl]-3-(2-methylpropyl)-, (3S,7R,10R,13E,16S)-

There total 5 articles about 1,4-Dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone, 10-[(3-chloro-4-methoxyphenyl)methyl]-7-methyl-16-[(1R,2E)-1-methyl-3 -phenyl-2-propenyl]-3-(2-methylpropyl)-, (3S,7R,10R,13E,16S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 193071-11-3
(S)-2-((R)-3-Amino-butyryloxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-1-carboxy-2-(3-chloro-4-methoxy-phenyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester

: 193070-91-6
(E)-(3S,7R,10R,16S)-10-(3-Chloro-4-methoxy-benzyl)-3-isobutyl-7-methyl-16-((E)-(R)-1-methyl-3-phenyl-allyl)-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone

Guidance literature:: With pentafluorophenyl diphenyl-phosphinate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 25 ℃;
DOI:10.1016/S0960-894X(98)00682-9

Reference yield:

: 193071-07-7
(S)-2-((R)-3-tert-Butoxycarbonylamino-butyryloxy)-4-methyl-pentanoic acid

: 193070-91-6
(E)-(3S,7R,10R,16S)-10-(3-Chloro-4-methoxy-benzyl)-3-isobutyl-7-methyl-16-((E)-(R)-1-methyl-3-phenyl-allyl)-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / DCC, DMAP / CH₂Cl₂ / 0 - 25 °C

2: Zn, AcOH

3: TFA / 25 °C

4: 87 percent / FDPP, DIEA / dimethylformamide / 25 °C

With dmap; pentafluorophenyl diphenyl-phosphinate; acetic acid; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; zinc; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(98)00682-9

Reference yield:

: 193071-04-4
(S)-2-((R)-3-tert-Butoxycarbonylamino-butyryloxy)-4-methyl-pentanoic acid allyl ester

: 193070-91-6
(E)-(3S,7R,10R,16S)-10-(3-Chloro-4-methoxy-benzyl)-3-isobutyl-7-methyl-16-((E)-(R)-1-methyl-3-phenyl-allyl)-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone

Guidance literature:: Multi-step reaction with 5 steps

1: Pd(PPh₃)4, N-methylmorpholine / tetrahydrofuran / 25 °C

2: 95 percent / DCC, DMAP / CH₂Cl₂ / 0 - 25 °C

3: Zn, AcOH

4: TFA / 25 °C

5: 87 percent / FDPP, DIEA / dimethylformamide / 25 °C

With 4-methyl-morpholine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; pentafluorophenyl diphenyl-phosphinate; acetic acid; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; zinc; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(98)00682-9