Toliprolol

Base Information

Chemical Name:Toliprolol
CAS No.:2933-94-0
Molecular Formula:C13H21 N O2
Molecular Weight:223.315
Hs Code.:2922299090
European Community (EC) Number:220-905-6
UNII:DCP58J201D
DSSTox Substance ID:DTXSID50863061
Nikkaji Number:J7.942A
Wikipedia:Toliprolol
Wikidata:Q15633990
NCI Thesaurus Code:C90803
ChEMBL ID:CHEMBL67096
Mol file:2933-94-0.mol

Synonyms:Doberol;ICI 45,763;KO 592;KO-592;KOE 592;MHIP;toliprolol

Suppliers and Price of Toliprolol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
TOLIPROLOL 95.00%
5MG
$ 498.72

Total 11 raw suppliers

Chemical Property of Toliprolol

Chemical Property:

Vapor Pressure:8.6E-06mmHg at 25°C
Melting Point:75-76°; mp 79°
Boiling Point:359.4°Cat760mmHg
Flash Point:171.2°C
PSA：41.49000
Density:1.018g/cm³
LogP:2.12360
XLogP3:1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:223.157228913
Heavy Atom Count:16
Complexity:185

Purity/Quality:

99% ^*data from raw suppliers

TOLIPROLOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=CC=C1)OCC(CNC(C)C)O

Technology Process of Toliprolol

There total 5 articles about Toliprolol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 2186-25-6
m-tolyl glycidyl ether

: 75-31-0
isopropylamine

: 2933-94-0
toliprolol

Guidance literature:: at 50 ℃;
DOI:10.1021/jm800227h

Reference yield:

: 108-39-4
3-methyl-phenol

: 2933-94-0
toliprolol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetone / Reflux

2: Na-β-zeolite / isopropyl alcohol / 12 h / 20 °C

With potassium carbonate; In isopropyl alcohol; acetone;
DOI:10.1039/c4cy00594e