2-(1-carboxy-2-phenylethyl)benzoic acid

Base Information

• Chemical Name: 2-(1-carboxy-2-phenylethyl)benzoic acid
• CAS No.: 2897-88-3
• Molecular Formula: C16H14 O4
• Molecular Weight: 270.285
• Mol file: 2897-88-3.mol

Synonyms:Benzoicacid, o-(a-carboxyphenethyl)- (7CI,8CI);Hydratropic acid, o-carboxy-b-phenyl-; Hydrocinnamic acid, a-(o-carboxyphenyl)-

Chemical Property of 2-(1-carboxy-2-phenylethyl)benzoic acid

Chemical Property:

• Vapor Pressure: 9.9E-09mmHg at 25°C
• Boiling Point: 445.8°Cat760mmHg
• Flash Point: 237.6°C
• Density: 1.303g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(1-carboxy-2-phenylethyl)benzoic acid

There total 11 articles about 2-(1-carboxy-2-phenylethyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methyl 2-(1-methoxy-1-oxo-3-phenylpropan-2-yl)benzoate (1269514-67-1) → 2-(1-carboxy-2-phenylethyl)benzoic acid (2897-88-3)

Guidance literature:

methyl 2-(1-methoxy-1-oxo-3-phenylpropan-2-yl)benzoate; With potassium hydroxide; In methanol; water; for 1h; Reflux;

With hydrogenchloride; In methanol; water;

DOI:10.1016/j.ejmech.2010.11.033

Reference yield:

2-(2-cyano-phenyl)-3-phenyl-propionitrile (1071102-35-6) → 2-(1-carboxy-2-phenylethyl)benzoic acid (2897-88-3)

Guidance literature:

With hydrogenchloride; at 200 - 220 ℃; im Rohr;

Reference yield:

dimethyl homophthalate (716-43-8) → 2-(1-carboxy-2-phenylethyl)benzoic acid (2897-88-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 13 h / -78 - 20 °C / Inert atmosphere

2.1: potassium hydroxide / methanol; water / 1 h / Reflux

With n-butyllithium; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; methanol; water;

DOI:10.1016/j.ejmech.2010.11.033

upstream raw materials:

diethyl homophthalate

triphenylmethyl sodium

2-(2-cyano-phenyl)-3-phenyl-propionitrile

2-(2-carboxy-phenyl)-3-phenyl-acrylic acid

Downstream raw materials:

4-benzyl-2-benzyloxy-isoquinoline-1,3(2H,4H)-dione

4-benzyl-2-hydroxy-isoquinoline-1,3(2H,4H)-dione

11-benzyl-1-oxo-1,2,3,4-tetrahydro-1λ⁴-[1,3]thiazino[3,2-b]isoquinolin-6-one

11-benzyl-3,4-dihydro-2H-[1,3]thiazino[3,2-b]isoquinolin-6-one