methyl 2-(2-methoxy-2-oxoethyl)benzenecarboxylate

Base Information

• Chemical Name: methyl 2-(2-methoxy-2-oxoethyl)benzenecarboxylate
• CAS No.: 716-43-8
• Molecular Formula: C11H12 O4
• Molecular Weight: 208.214
• Hs Code.: 2918990090
• Mol file: 716-43-8.mol

Synonyms:o-Toluicacid, a-carboxy-, dimethyl ester(7CI,8CI); Dimethyl homophthalate; Dimethyl o-(carboxymethyl)benzoate; Dimethyla-carboxy-o-toluate; Methyl2-(methoxycarbonylmethyl)benzoate; NSC 76500

Chemical Property of methyl 2-(2-methoxy-2-oxoethyl)benzenecarboxylate

Chemical Property:

• Vapor Pressure: 0.000924mmHg at 25°C
• Melting Point: 54.8-56.2 °C
• Boiling Point: 303.5°C at 760 mmHg
• Flash Point: 148.9°C
• PSA: 52.60000
• Density: 1.155g/cm³
• LogP: 1.18870

Purity/Quality:

98%min ^*data from raw suppliers

Methyl2-(2-Methoxy-2-oxoethyl)benzenecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 2-(2-methoxy-2-oxoethyl)benzenecarboxylate

There total 28 articles about methyl 2-(2-methoxy-2-oxoethyl)benzenecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + Homophthalic acid (89-51-0) → dimethyl homophthalate (716-43-8)

Guidance literature:

With thionyl chloride; Reflux;

DOI:10.1007/s00044-020-02662-w

Reference yield: 96.0%

methanol (67-56-1) + Homophthalic acid (89-51-0) → dimethyl homophthalate (716-43-8) + o-(methoxycarbonylmethyl)benzoic acid (14736-50-6)

Guidance literature:

With thionyl chloride; at 25 - 27 ℃; for 10h;

Reference yield: 88.0%

methanol (67-56-1) + 1-diazoindan-2,3-dione (147688-73-1) → dimethyl homophthalate (716-43-8) + benzocyclobutenone-2-carboxylic acid methyl ester (17539-22-9)

Guidance literature:

Ambient temperature; Irradiation;

DOI:10.1021/jo00059a068

upstream raw materials:

diazomethane

Homophthalic acid

methanol

phthalic anhydride

Downstream raw materials:

2-(1-methoxycarbonyl-2,2-diphenyl-vinyl)-benzoic acid

methyl β-(3,4-methylenedioxyphenyl)-α-(2-carboxyphenyl)acrylate

methyl ester of 2-(2-carboxyphenyl)-3-phenylacrylic acid

2-(1-methoxycarbonyl-2-methyl-propenyl)-benzoic acid

Refernces

• 1、 Senaweera, Sameera,He, Tianyu,Cui, Haixi,Aihara, Hideki,Wang, Zhengqiang. "4-benzylideneisoquinoline-1,3(2H,4H)-diones as tyrosyl DNA phosphodiesterase 2 (TDP2) inhibitors". . p. 371 - 386. Retrieved 2020/11/23.
• 2、 -. "IDO/TDO Inhibitor". Paragraph 0493-0496; 0581-0584. . Retrieved 2020/08/19.