2-Pentenoic acid, 2-(methoxymethoxy)-5-[5-methoxy-2-[3-(methoxymethylamino)-3-oxo-1- propenyl]phenyl]-, methyl ester, (E,E)-

Base Information

• Chemical Name: 2-Pentenoic acid, 2-(methoxymethoxy)-5-[5-methoxy-2-[3-(methoxymethylamino)-3-oxo-1- propenyl]phenyl]-, methyl ester, (E,E)-
• CAS No.: 193337-41-6
• Molecular Formula: C20H27NO7
• Molecular Weight: 393.437
• Mol file: 193337-41-6.mol

Synonyms:

Chemical Property of 2-Pentenoic acid, 2-(methoxymethoxy)-5-[5-methoxy-2-[3-(methoxymethylamino)-3-oxo-1- propenyl]phenyl]-, methyl ester, (E,E)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Pentenoic acid, 2-(methoxymethoxy)-5-[5-methoxy-2-[3-(methoxymethylamino)-3-oxo-1- propenyl]phenyl]-, methyl ester, (E,E)-

There total 5 articles about 2-Pentenoic acid, 2-(methoxymethoxy)-5-[5-methoxy-2-[3-(methoxymethylamino)-3-oxo-1- propenyl]phenyl]-, methyl ester, (E,E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

diethyl (N-methoxy-N-methylcarbamoylmethyl)phosphonate (124931-12-0) + (E)-5-(2-Formyl-5-methoxy-phenyl)-2-methoxymethoxy-pent-2-enoic acid methyl ester (193337-38-1) → (E)-2-Methoxymethoxy-5-{5-methoxy-2-[(E)-2-(methoxy-methyl-carbamoyl)-vinyl]-phenyl}-pent-2-enoic acid methyl ester (193337-41-6)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at 0 ℃;

DOI:10.1055/s-1997-3255

Reference yield:

7-methoxy-1,2-dihydronaphthalene (52178-91-3) → (E)-2-Methoxymethoxy-5-{5-methoxy-2-[(E)-2-(methoxy-methyl-carbamoyl)-vinyl]-phenyl}-pent-2-enoic acid methyl ester (193337-41-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) O₃, 2.) DMS / 1.) MeOH, -78 deg C, 2.) rt

2: n-BuLi / tetrahydrofuran / 0 °C

3: 85 percent / n-BuLi / tetrahydrofuran / 0 °C

With n-butyllithium; 2,3-dimercapto-succinic acid; ozone; In tetrahydrofuran;

DOI:10.1055/s-1997-3255

Reference yield:

4-Methoxy-2-(3-oxo-propyl)-benzaldehyde (65272-95-9) → (E)-2-Methoxymethoxy-5-{5-methoxy-2-[(E)-2-(methoxy-methyl-carbamoyl)-vinyl]-phenyl}-pent-2-enoic acid methyl ester (193337-41-6)

Guidance literature:

Multi-step reaction with 2 steps

1: n-BuLi / tetrahydrofuran / 0 °C

2: 85 percent / n-BuLi / tetrahydrofuran / 0 °C

With n-butyllithium; In tetrahydrofuran;

DOI:10.1055/s-1997-3255

upstream raw materials:

diethyl (N-methoxy-N-methylcarbamoylmethyl)phosphonate

(E)-5-(2-Formyl-5-methoxy-phenyl)-2-methoxymethoxy-pent-2-enoic acid methyl ester

7-methoxy-1,2-dihydronaphthalene

4-Methoxy-2-(3-oxo-propyl)-benzaldehyde

Downstream raw materials:

(E)-3-[2-((E)-5-Hydroxy-4-methoxymethoxy-pent-3-enyl)-4-methoxy-phenyl]-propenal

(E)-3-[2-((E)-5-Chloro-4-methoxymethoxy-pent-3-enyl)-4-methoxy-phenyl]-propenal

(E)-3-[2-((E)-5-Chloro-4-methoxymethoxy-pent-3-enyl)-4-methoxy-phenyl]-prop-2-en-1-ol

tert-Butyl-{(E)-3-[2-((E)-5-chloro-4-methoxymethoxy-pent-3-enyl)-4-methoxy-phenyl]-allyloxy}-dimethyl-silane